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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
1978-6-28
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|
pubmed:abstractText |
Several protein synthesis inhibitors were as effective as the inducers hydrocortisone or cyclic AMP in elevating rat liver tyrosine aminotransferase mRNA levels when assayed in the wheat germ cell-free translational system. Cycloheximide, emetine, or puromycin increased this mRNA activity 6- to 7-fold within 4 h after in vivo administration. No increase in total hepatic mRNA levels or tryptophan oxygenase mRNA was found after treatment with these protein synthesis inhibitors. Furthermesults suggest that a short lived protein may specifically regulate the level of functional hepatic tyrosine aminotransferase mRNA or that ongoing translation of this mRNA is required for its degradation.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0021-9258
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
10
|
|
pubmed:volume |
253
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2895-7
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:25275-Animals,
pubmed-meshheading:25275-Bucladesine,
pubmed-meshheading:25275-Cyclic AMP,
pubmed-meshheading:25275-Cycloheximide,
pubmed-meshheading:25275-Emetine,
pubmed-meshheading:25275-Hydrocortisone,
pubmed-meshheading:25275-Liver,
pubmed-meshheading:25275-Male,
pubmed-meshheading:25275-Puromycin,
pubmed-meshheading:25275-RNA, Messenger,
pubmed-meshheading:25275-Rats,
pubmed-meshheading:25275-Theophylline,
pubmed-meshheading:25275-Transcription, Genetic,
pubmed-meshheading:25275-Tyrosine Transaminase
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|
pubmed:year |
1978
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|
pubmed:articleTitle |
Induction of hepatic tyrosine aminotransferase mRNA by protein synthesis inhibitors.
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|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
