Linked Life Data

2527308

Source:http://linkedlifedata.com/resource/pubmed/id/2527308

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-9-18
pubmed:abstractText
Peritoneal macrophages were harvested from both healthy mice and mice with diabetes induced by intravenous injection of streptozotocin. After incubation with normal plasma very low density lipoprotein (n-VLDL) from swine for 24 h, the content of triglyceride (TG) in macrophages from diabetic mice was higher than that in the controls, and it was the same with the concentration of free fatty acid (FFA) in medium. The basic concentration of cholesterol ester (ChE) in macrophages from diabetic mice was also higher than that of the controls. After incubation with beta-VLDL from hypercholesterolemic rabbit for 48 h, no alteration in ChE content was found in the cells. On the contrary, the content of ChE in the cells from the controls was accumulated by saturating. The levels of FFA in the medium of the diabetic group were still higher than those of the controls. These results demonstrated that the metabolic function of peritoneal macrophages in diabetic mice was altered. The uptake and degradation of n-VLDL and the endogenous cholesterol synthesis were increased, but the uptake of beta-VLDL was lower. In this paper, the possible mechanism and the relationship between atherosclerosis and diabetes are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0257-716X
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
53-7
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Metabolism of n-VLDL and beta-VLDL in peritoneal macrophages from diabetic mice.
pubmed:publicationType
Journal Article