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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1989-9-1
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pubmed:abstractText |
Monocytes and endothelial cells were stimulated in co-culture with allogeneic lymphocytes to produce thromboplastin (TPL). The induction was biphasic, an early response (8-24 h) was greatly augmented by cyclosporin A (CS) (0.5-5 micrograms/ml) whereas the late response (day 3-4) was inhibited. Prednisolone inhibited both responses. Both drugs inhibited lymphocyte proliferation. Interferon-gamma decreased MLC TPL activity but increased thymidine incorporation. CD4+ cells were instrumental in inducing the early TPL peak in monocytes, whereas CD8+ cells decreased the TPL effect. With endothelial cells both T cell classes were equally effective. Conditioned medium from MLC as well as from co-cultures of endothelial cells and lymphocytes induced early TPL synthesis in endothelial cells. Upon allogeneic stimulation monocytes, but not endothelial cells, produced a significant amount of F-VII, most of which was apparently undercarboxylated.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-1201214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-2408804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-2422040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-2945864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-3051564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-3088118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-3108404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-3116086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-3123108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-3129778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-3355538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-3753996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-3781641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-3920795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-4026807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-4944225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-5336793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-6224886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-6244830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-6362711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-6364491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-6445383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-6456921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-6848129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2526700-98070
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
428-33
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2526700-Cyclosporins,
pubmed-meshheading:2526700-Endothelium, Vascular,
pubmed-meshheading:2526700-Factor VII,
pubmed-meshheading:2526700-Humans,
pubmed-meshheading:2526700-Interferon-gamma,
pubmed-meshheading:2526700-Isoantigens,
pubmed-meshheading:2526700-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:2526700-Lymphocytes,
pubmed-meshheading:2526700-Monocytes,
pubmed-meshheading:2526700-Prednisolone,
pubmed-meshheading:2526700-Thromboplastin
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pubmed:year |
1989
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pubmed:articleTitle |
Allogenic induction of thromboplastin synthesis in monocytes and endothelial cells. Biphasic effect of cyclosporin A.
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pubmed:affiliation |
Surgical Department B, Rikshospitalet, Oslo, Norway.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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