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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1989-7-24
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pubmed:abstractText |
Apolipoprotein(a), apo(a), contains 37 repeats structurally homologous to kringle 4 structures of the fibrinolysis zymogen plasminogen. The aim of the study was to explore the functional analogy between apolipoprotein(a) and plasminogen in the binding to the kringle-4-binding plasma protein, tetranectin. With a modified crossed immunoelectrophoresis technique, reversible binding between lipoprotein(a) and tetranectin could be demonstrated with an apparent Kd of 0.013 muMol/l. Lys- and Glu-plasminogen showed an apparent Kd of 0.5 muMol/l. Binding of lipoprotein(a) to fibrin and to fibrin-bound tetranectin was found to be negligible. The absence of fibrin binding of lipoprotein(a) excludes a potential mechanism of coexistence of fibrin and lipid deposits in arterial diseases and does not provide for a link between lipoprotein and the clotting system. Plasminogen and lipoprotein(a) show functional analogy in their binding to tetranectin, but tetranectin primarily targets at lipoprotein(a).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
161
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
427-33
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2525378-Blood Proteins,
pubmed-meshheading:2525378-Fibrin,
pubmed-meshheading:2525378-Humans,
pubmed-meshheading:2525378-Immunoelectrophoresis, Two-Dimensional,
pubmed-meshheading:2525378-Lectins, C-Type,
pubmed-meshheading:2525378-Lipoprotein(a),
pubmed-meshheading:2525378-Lipoproteins,
pubmed-meshheading:2525378-Lipoproteins, LDL,
pubmed-meshheading:2525378-Plasminogen,
pubmed-meshheading:2525378-Protein Binding,
pubmed-meshheading:2525378-Protein Conformation,
pubmed-meshheading:2525378-Solubility,
pubmed-meshheading:2525378-Structure-Activity Relationship
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pubmed:year |
1989
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pubmed:articleTitle |
Functional analogy between lipoprotein(a) and plasminogen in the binding to the kringle 4 binding protein, tetranectin.
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pubmed:affiliation |
Gaubius Institute TNO, Leiden, The Netherlands.
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pubmed:publicationType |
Journal Article,
In Vitro
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