Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1989-7-14
|
| pubmed:abstractText |
We report the molecular, cytogenetic, and immunologic characterization of three hematologic malignancies that contained characteristic t(2;5) chromosomal translocations. The clinicopathologic features in all three cases fit the disease spectrum of so-called malignant histiocytosis (MH). All cases expressed activation antigens including Ki-1 (CD 30), but no lineage-restricted pattern of cellular antigen expression was observed. Cell lines SUP-M2 and SU-DHL-1 established from two of the cases showed rearranged beta T-cell receptor (beta TCR) genes nonproductive of full-length beta TCR mRNA and therefore not helpful in unequivocal establishment of lineage derivation. The common cytogenetic feature was a reciprocal translocation between chromosomes 2 and 5, involving bands 2p23 and 5q35 near the reported chromosomal locations of the N-myc and c-fms genes, respectively. Normal-sized and truncated c-fms RNAs were observed in both cell lines, whereas no N-myc transcripts were detected. Sequence analysis of the truncated fms RNA showed that it consisted of the 3' half of the c-fms mRNA, but its derivation was not the result of a structural alteration of the c-fms gene. Our studies show that the t(2;5) does not involve the N-myc and c-fms protooncogenes and that this cytogenetic abnormality may be characteristic of a subset of primitive malignancies with an indeterminate lineage but with clinicopathologic features of so-called MH.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0006-4971
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
73
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2155-64
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2525056-Adult,
pubmed-meshheading:2525056-Antigens, Differentiation,
pubmed-meshheading:2525056-Base Sequence,
pubmed-meshheading:2525056-Cell Line,
pubmed-meshheading:2525056-Child,
pubmed-meshheading:2525056-Child, Preschool,
pubmed-meshheading:2525056-Chromosomes, Human, Pair 2,
pubmed-meshheading:2525056-Chromosomes, Human, Pair 5,
pubmed-meshheading:2525056-Female,
pubmed-meshheading:2525056-Histiocytic Sarcoma,
pubmed-meshheading:2525056-Humans,
pubmed-meshheading:2525056-Karyotyping,
pubmed-meshheading:2525056-Male,
pubmed-meshheading:2525056-Molecular Sequence Data,
pubmed-meshheading:2525056-Oncogenes,
pubmed-meshheading:2525056-Phenotype,
pubmed-meshheading:2525056-Proto-Oncogenes,
pubmed-meshheading:2525056-Receptors, Antigen, T-Cell,
pubmed-meshheading:2525056-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:2525056-Transcription, Genetic,
pubmed-meshheading:2525056-Translocation, Genetic
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Lack of involvement of the c-fms and N-myc genes by chromosomal translocation t(2;5)(p23;q35) common to malignancies with features of so-called malignant histiocytosis.
|
| pubmed:affiliation |
Genetics Center of Southwest Biomedical Research Institute, Scottsdale, AZ.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports,
Research Support, Non-U.S. Gov't
|