rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4906
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pubmed:dateCreated |
1989-6-23
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pubmed:abstractText |
The staphylococcal toxins are responsible for a number of diseases in man and other animals. Many of them have also long been known to be powerful T cell stimulants. They do not, however, stimulate all T cells. On the contrary, each toxin reacts with human T cells bearing particular V beta sequences as part of their receptors for major histocompatibility complex protein-associated antigen. The specificity of these toxins for V beta s puts them in the recently described class of superantigens and may account for the differential sensitivity of different individuals to the toxic effects of these proteins.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Toxins,
http://linkedlifedata.com/resource/pubmed/chemical/HLA Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0036-8075
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
244
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
811-3
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:2524876-Antibodies,
pubmed-meshheading:2524876-Antigens, CD3,
pubmed-meshheading:2524876-Antigens, CD8,
pubmed-meshheading:2524876-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:2524876-Bacterial Toxins,
pubmed-meshheading:2524876-HLA Antigens,
pubmed-meshheading:2524876-Humans,
pubmed-meshheading:2524876-Immunoassay,
pubmed-meshheading:2524876-Lymphocyte Activation,
pubmed-meshheading:2524876-Receptors, Antigen, T-Cell,
pubmed-meshheading:2524876-Staphylococcus,
pubmed-meshheading:2524876-T-Lymphocytes
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pubmed:year |
1989
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pubmed:articleTitle |
V beta-specific stimulation of human T cells by staphylococcal toxins.
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pubmed:affiliation |
Howard Hughes Medical Institute, Denver, CO.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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