Linked Life Data

2524506

Source:http://linkedlifedata.com/resource/pubmed/id/2524506

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1989-7-3
pubmed:abstractText
The spontaneous proliferative response (SPR) of peripheral blood lymphocytes, as a measure of the autologous mixed lymphocyte reaction (AMLR), has been found to be depressed in adults with chronic inflammatory periodontal disease (CIPD). The aim of the present study was to test the hypothesis that initial treatment of CIPD in adults restores the SPR to normal levels. 10 periodontal disease subjects (mean probing attachment loss of 4.2 mm and a mean bleeding index of 0.65) and 10 age- and sex-matched healthy control subjects were studied. The SPR for each patient was evaluated on days 3, 5, 7, 9 and 11 in culture, before and after initial treatment for CIPD. The peak SPR, which occurred at day 5, was depressed in the untreated periodontal disease subjects compared to the healthy control subjects (p less than 0.01). In addition, the kinetics of the SPR were found to be significantly different in 4 of the 10 parameters compared with the untreated periodontal disease patients and the healthy control subjects. After treatment, there was a significant reduction in probing attachment loss and bleeding indexes (p less than 0.001). In addition, the magnitude of the peak SPR was not significantly different from that of the healthy control subjects. Nevertheless, a difference in 1 of the 10 kinetic parameters persisted, which suggested that complete restoration of the SPR to normal had not occurred so soon after treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0303-6979
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
271-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Effect of initial treatment of chronic inflammatory periodontal disease in adults on spontaneous peripheral blood lymphocyte proliferation.
pubmed:affiliation
Department of Social and Preventive Dentistry, University of Queensland, Brisbane, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't