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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1989-7-3
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pubmed:abstractText |
To study T cell tolerance, transgenic mice were generated that expressed the Mlsa-reactive T cell receptor (TCR) beta chain V beta 8.1 (cDNA) under the control of the H-2Kb promoter/immunoglobulin heavy chain enhancer on approximately 90% of peripheral T cells. In transgenic mice bearing Mlsa, thymocytes expressing the TCR at a high density were deleted and the percentage of Thy 1.2+ lymph node cells was reduced. The CD4/CD8 ratio of mature T cells was reversed in Mlsa and Mlsb transgenic mice independent of the H-2. RNA analysis and immunofluorescence with TCR V beta-specific antibodies revealed that expression of endogenous TCR beta genes was suppressed. Both Mlsa and Mlsb TCR beta chain transgenic mice mounted a T-cell-dependent IgG response against viral antigens, whereas the capacity to generate alloreactive and virus-specific cytotoxic T cells was impaired in TCR beta chain transgenic Mlsa, but not in transgenic Mlsb mice.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2524380-2415139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2524380-2432150,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2524380-2961577,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2524380-7188699
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Minor Lymphocyte Stimulatory...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
719-27
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2524380-Animals,
pubmed-meshheading:2524380-Antigens, CD8,
pubmed-meshheading:2524380-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:2524380-Antigens, Surface,
pubmed-meshheading:2524380-Enhancer Elements, Genetic,
pubmed-meshheading:2524380-Gene Expression Regulation,
pubmed-meshheading:2524380-Genes, Immunoglobulin,
pubmed-meshheading:2524380-Immune Tolerance,
pubmed-meshheading:2524380-Mice,
pubmed-meshheading:2524380-Mice, Transgenic,
pubmed-meshheading:2524380-Minor Lymphocyte Stimulatory Antigens,
pubmed-meshheading:2524380-Receptors, Antigen, T-Cell,
pubmed-meshheading:2524380-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:2524380-T-Lymphocytes
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pubmed:year |
1989
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pubmed:articleTitle |
T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice.
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pubmed:affiliation |
Department of Experimental Pathology, University Hospital, Zürich, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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