Linked Life Data

2524015

Source:http://linkedlifedata.com/resource/pubmed/id/2524015

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1989-6-16
pubmed:abstractText
Mature organotypic cultures of rat corticostriatal system (CXCA cultures) or caudate nucleus (CA cultures) were chronically exposed to 100 nM quinolinic acid (QUIN) for up to 7 weeks. Light and electron microscopic analysis showed no pathological changes in QUIN-exposed CA cultures or in control cultures incubated in regular feeding medium for this time period. In contrast, in CXCA cultures exposed to QUIN, there was focal degeneration characterized by the presence of vacuoles in neuropil, swollen dendrites, occasional swollen post-synaptic elements and degenerated neurons. Prolonged exposure to only slightly hyper-physiological concentrations of QUIN may cause neuronal death in slowly progressive neurodegenerative disorders such as Huntington's disease (HD).
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
271-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Prolonged exposure to submicromolar concentrations of quinolinic acid causes excitotoxic damage in organotypic cultures of rat corticostriatal system.
pubmed:affiliation
Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.