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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1989-5-24
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pubmed:abstractText |
A total of 624 consecutive eligible patients undergoing abdominal operations received a single preoperative dose of amoxycillin/clavulanic acid (1.2 g Augmentin) for the prophylaxis of surgical wound infection. They were randomised to have the antibiotic injected intravenously at induction of anaesthesia (n = 328) or infiltrated subcutaneously along the line of the proposed incision (n = 296). The incidence of wound infections was considerably lower in the group given the antibiotic into the abdominal wall (8.4% compared with 15.9%--chi 2 = 7.90, P = 0.005). No significant differences were found in the incidence of other major or minor infective or non-infective postoperative complications between the groups. It is concluded that preincisional intraparietal injection is more effective than intravenous injection of Augmentin for the prophylaxis of surgical wound infection.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0035-8843
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
97-100
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2523210-Abdomen,
pubmed-meshheading:2523210-Abdominal Muscles,
pubmed-meshheading:2523210-Administration, Cutaneous,
pubmed-meshheading:2523210-Adult,
pubmed-meshheading:2523210-Amoxicillin,
pubmed-meshheading:2523210-Amoxicillin-Potassium Clavulanate Combination,
pubmed-meshheading:2523210-Clavulanic Acids,
pubmed-meshheading:2523210-Clinical Trials as Topic,
pubmed-meshheading:2523210-Drug Therapy, Combination,
pubmed-meshheading:2523210-Female,
pubmed-meshheading:2523210-Humans,
pubmed-meshheading:2523210-Male,
pubmed-meshheading:2523210-Middle Aged,
pubmed-meshheading:2523210-Premedication,
pubmed-meshheading:2523210-Surgical Wound Infection
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pubmed:year |
1989
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pubmed:articleTitle |
Preincisional intraparietal Augmentin in abdominal operations.
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pubmed:affiliation |
Scarborough Hospital, N Yorkshire.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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