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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1989-4-24
|
| pubmed:abstractText |
Histological and immunohistochemical features of 87 patients with conventionally diagnosed Ewing's sarcoma were studied retrospectively on routinely processed material and evaluated with regard to prognostic significance. 74% were convincingly positive when stained for vimentin, 13% were doubtful, and 13% were negative. A varying degree of positivity for neuron-specific enolase (NSE) was found in 15%; these cases all co-expressed vimentin. A single tumour contained scattered cytokeratin-positive cells. Positivity for the leukocyte common antigen (LCA) could be demonstrated in three cases; these were excluded from the statistical analysis of prognostic factors. Growth pattern, soft tissue invasion, monomorphic or dimorphic cell population, and PAS-, NSE- or vimentin-positivity did not influence survival significantly. However, prognosis was increasingly poor with increasing degree of necrosis: median survival was 28 months for grade I necrosis (less than 10%), 16 months for grade II (10-50%), and 11 months for grade III (greater than 50%), p less than 0.0005. A mitosis count of less than 1 per high-powerfield (HPF) was correlated to a median survival of 26 months, greater than or equal to 1 per HPF to 12 months, p less than 0.05. The findings indicate some degree of heterogeneity in Ewing's sarcoma which may be related to primitive peripheral neuroectodermal tumours (PNETs), or be a true blastoma. In future trials, diagnostic criteria (including immunohistochemistry) should be clearly defined and materials should be large enough to allow for stratification according to prognostic factors.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphopyruvate Hydratase,
http://linkedlifedata.com/resource/pubmed/chemical/Vimentin
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0174-7398
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
414
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
243-51
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2522693-Adolescent,
pubmed-meshheading:2522693-Adult,
pubmed-meshheading:2522693-Antigens, CD45,
pubmed-meshheading:2522693-Antigens, Differentiation,
pubmed-meshheading:2522693-Child,
pubmed-meshheading:2522693-Child, Preschool,
pubmed-meshheading:2522693-Female,
pubmed-meshheading:2522693-Histocompatibility Antigens,
pubmed-meshheading:2522693-Humans,
pubmed-meshheading:2522693-Immunohistochemistry,
pubmed-meshheading:2522693-Infant,
pubmed-meshheading:2522693-Male,
pubmed-meshheading:2522693-Middle Aged,
pubmed-meshheading:2522693-Phosphopyruvate Hydratase,
pubmed-meshheading:2522693-Prognosis,
pubmed-meshheading:2522693-Retrospective Studies,
pubmed-meshheading:2522693-Sarcoma, Ewing,
pubmed-meshheading:2522693-Vimentin
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Ewing's sarcoma. A retrospective study of histological and immunohistochemical factors and their relation to prognosis.
|
| pubmed:affiliation |
Bone and Soft Tissue Tumour Centres of Copenhagen, Denmark.
|
| pubmed:publicationType |
Journal Article
|