| pubmed-article:2522495 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2522495 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2522495 | lifeskim:mentions | umls-concept:C0021755 | lld:lifeskim |
| pubmed-article:2522495 | lifeskim:mentions | umls-concept:C1156237 | lld:lifeskim |
| pubmed-article:2522495 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:2522495 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2522495 | pubmed:dateCreated | 1989-4-24 | lld:pubmed |
| pubmed-article:2522495 | pubmed:abstractText | We have studied the control and significance of IL-1 production in human leukocyte cultures during accessory cell-dependent, T lymphocyte mitogenesis using sensitive bioassays and immunolabeling techniques. In primary antigen-dependent systems like the MLR, IL-1 production was not detected in accessory cells (monocytes, dendritic cells) or T cells, suggesting that it is not an early product in these responses. However, monocytes could be induced to make IL-1 after interacting with sensitized antigen-specific T cells. Both alloreactive T cell clones or freshly prepared lymphoblasts induced IL-1 provided the monocytes carried the HLA-DR antigens to which the T cells were initially sensitized. Even in these circumstances, dendritic cells and B cells failed to make IL-1. The mechanism whereby activated T cells induce IL-1 in monocytes was explored. Supernatants from cocultures of monocytes and T cells or several recombinant cytokines induced little or no IL-1. A more potent antigen independent pathway of IL-1 induction was identified. IL-1 could be induced in third-party HLA-DR nonspecific monocytes in cocultures of alloreactive T cell clones or blasts and HLA-DR-specific dendritic cells. The induction was factor independent since dendritic cells and T blasts placed in a chamber separate from third-party monocytes by a semipermeable membrane did not induce monocyte IL-1. These results suggest that a cell contact mechanism rather than an IL-1-inducing factor leads to IL-1 production. The role of IL-1 in T cell proliferation was tested with a polyclonal anti-IL-1 antibody. The antibody failed to block the proliferation of primary T cells, or alloreactive T cell clones and blasts stimulated with HLA-specific monocytes or dendritic cells, even though IL-1 in the medium was neutralized. | lld:pubmed |
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| pubmed-article:2522495 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2522495 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2522495 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2522495 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2522495 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:2522495 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:2522495 | pubmed:author | pubmed-author:FriedmanS MSM | lld:pubmed |
| pubmed-article:2522495 | pubmed:author | pubmed-author:LawL NLN | lld:pubmed |
| pubmed-article:2522495 | pubmed:author | pubmed-author:SteinmanR MRM | lld:pubmed |
| pubmed-article:2522495 | pubmed:author | pubmed-author:BhardwajNN | lld:pubmed |
| pubmed-article:2522495 | pubmed:author | pubmed-author:CrowM KMK | lld:pubmed |
| pubmed-article:2522495 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2522495 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2522495 | pubmed:volume | 169 | lld:pubmed |
| pubmed-article:2522495 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2522495 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2522495 | pubmed:pagination | 1121-36 | lld:pubmed |
| pubmed-article:2522495 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2522495 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2522495 | pubmed:articleTitle | Interleukin 1 production during accessory cell-dependent mitogenesis of T lymphocytes. | lld:pubmed |
| pubmed-article:2522495 | pubmed:affiliation | Rockefeller University, New York, New York 10021. | lld:pubmed |
| pubmed-article:2522495 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2522495 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2522495 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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