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pubmed-article:2521448pubmed:abstractTextQualitative and quantitative expression of m.RNA coding for Peptidyl-Glycine alpha-Amidating Monooxygenase (PAM) in the developing rat pancreas was investigated by Northern and dot blot hybridization, with a bovine PAM c.DNA probe (0.7 kb fragment). A specific hybridization signal was evidenced for a 3.7 kb m.RNA species. Measurement of PAM m. RNA rate during the rat pancreas ontogenesis revealed a biphasic profile which appeared corelated with that of gastrin and TRH m.RNA respectively. On the other hand, streptozotocin-treatment resulted in a 50% decrease of PAM m.RNA levels.lld:pubmed
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pubmed-article:2521448pubmed:articleTitleOntogenetic expression of peptidyl-glycine alpha-amidating monooxygenase mRNA in the rat pancreas.lld:pubmed
pubmed-article:2521448pubmed:affiliationLaboratoire de Neuroendocrinologie Expérimentale, INSERM U, 297, Faculté de Médecine Nord, Marseille, France.lld:pubmed
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