Linked Life Data

2521280

Source:http://linkedlifedata.com/resource/pubmed/id/2521280

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1989-2-6
pubmed:abstractText
These experiments investigated the effect of halothane or fentanyl anesthesia on plasma atrial natriuretic polypeptide (ANP) and angiotensin II (AII) concentrations and the response to a 30% blood volume load in rats. Halothane (1.1% and 2.2% inspired) or fentanyl (50 and 200 micrograms/kg) anesthesia alone produced little change in basal plasma ANP levels but did increase plasma AII levels above unanesthetized baseline concentrations. A 30% blood volume load in conscious rats produced a transient increase in blood pressure and central venous pressure, a threefold rise in plasma ANP, and a decrease in AII. These effects were not significantly altered by fentanyl anesthesia. In contrast, during 2.2% halothane anesthesia the increase in plasma ANP produced by volume loading was greater and the decrease in AII was abolished. These results indicate that fentanyl does not increase basal ANP levels or markedly change the hormonal response to a volume load. Altered responses seen during deep halothane anesthesia may result from cardiovascular changes or a direct stimulation of physiological mechanisms that release ANP.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0003-2999
pubmed:author
pubmed:issnType
Print
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
40-5
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Plasma atrial natriuretic polypeptide and angiotensin II in rats during anesthesia and volume loading.
pubmed:affiliation
Department of Anesthesiology, Michael Reese Hospital and Medical Center, Chicago, IL 60616.
pubmed:publicationType
Journal Article