Linked Life Data

2515963

Source:http://linkedlifedata.com/resource/pubmed/id/2515963

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1990-3-19
pubmed:abstractText
The in vitro activity of lomefloxacin in comparison to other recently developed quinolones was evaluated by determination of MICs for 89 test strains. Organisms tested included clinical isolates of gram-positive and gram-negative bacteria susceptible or resistant to quinolones, resistant mutants of Enterobacteriaceae, Pseudomonas aeruginosa, Staphylococcus aureus and Enterococcus faecalis obtained in vitro, and the wild type strain Escherichia coli K12 with its mutants na1A, nalB, nalC and nalB. The activity of lomefloxacin was similar to that of pefloxacin against gram-positive cocci and similar to that of norfloxacin against gram-negative bacteria. There was cross-resistance to all quinolones tested in pefloxacin resistant clinical isolates and in laboratory mutants. The activity of lomefloxacin was decreased against the Escherichia coli K12 mutants nalA and nalD but not nalB, whereas the nalC mutant showed increased susceptibility. Susceptible and mutant strains (n = 115) were used to establish the least-squares lines of regression with 5-micrograms and 10-micrograms lomefloxacin disks. Tests of the in vitro plasmid curing activity of lomefloxacin compared to other agents showed no statistically significant plasmid loss after treatment with lomefloxacin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0934-9723
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1048-52
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Antibacterial and plasmid curing activity of lomefloxacin in vitro.
pubmed:affiliation
Unité des Agents Antibactériens, CNRS UA 271, Centre National de Référence des Antibiotiques, Institut Pasteur, Paris, France.
pubmed:publicationType
Journal Article, Comparative Study