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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
1990-2-21
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pubmed:abstractText |
Effects of beraprost sodium (sodium(+/-)-(1R*,2R*,3aS*,8bS*)-2,3,3a,8b-tetrahydro-2-hydr oxy-1- [(E)-(3S*)-3-hydroxy-4-methyl-octen-6-ynyl]-1H-cyclopenta[b] benzofuran- 5-butyrate, TRK-100), a stable prostacyclin analogue, on the peripheral circulatory disturbances induced by various vasoconstrictive stimuli were studied. Orally administered beraprost sodium (10, 30 micrograms/kg) caused increase in skin blood flow in anesthetized rats and rise in skin temperature in conscious rats. Intravenously administered beraprost sodium (0.01-0.3 microgram/kg) reduced the recovery time of decreased pulse pressure by topical cooling of the leg in anesthetized rats. In conscious rabbits, intravenous infusion of beraprost sodium (10 micrograms/kg/min) inhibited the fluctuation of ear artery diameter, and dilated the ear artery and vein, resulting in a rise in the ear temperature. In anesthetized dogs, intravenously administered beraprost sodium (0.313-5 micrograms/kg) caused decrease in femoral blood flow and muscle blood flow in the hindlimb, however, it caused increase in skin blood flow at the hind leg instep. Furthermore, intra-arterially administered beraprost sodium (0.1-0.3 microgram/kg/min) under stimulation of lumbar sympathetic nerve caused increase in femoral artery blood flow and selective increase in the skin blood flow without affecting muscle blood flow.(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alprostadil,
http://linkedlifedata.com/resource/pubmed/chemical/Epoprostenol,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Aggregation Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents,
http://linkedlifedata.com/resource/pubmed/chemical/beraprost
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0004-4172
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1229-34
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:2514691-Alprostadil,
pubmed-meshheading:2514691-Animals,
pubmed-meshheading:2514691-Dogs,
pubmed-meshheading:2514691-Ear, External,
pubmed-meshheading:2514691-Epoprostenol,
pubmed-meshheading:2514691-Femoral Artery,
pubmed-meshheading:2514691-Male,
pubmed-meshheading:2514691-Muscles,
pubmed-meshheading:2514691-Platelet Aggregation Inhibitors,
pubmed-meshheading:2514691-Rabbits,
pubmed-meshheading:2514691-Rats,
pubmed-meshheading:2514691-Rats, Inbred Strains,
pubmed-meshheading:2514691-Regional Blood Flow,
pubmed-meshheading:2514691-Skin,
pubmed-meshheading:2514691-Skin Temperature,
pubmed-meshheading:2514691-Sympathetic Nervous System,
pubmed-meshheading:2514691-Vasoconstrictor Agents
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pubmed:year |
1989
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pubmed:articleTitle |
Effect of beraprost sodium on peripheral circulatory disturbances induced by various stimuli.
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pubmed:affiliation |
Toray Industries, Inc., Basic Research Laboratories, Kanagawa, Japan.
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pubmed:publicationType |
Journal Article
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