Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1990-2-14
pubmed:abstractText
1H-NMR and X-ray conformation studies of new muscarinergic dibenzodioxazocines have been carried out. It is suggested that EGYT-2347 (2-chloro-12-/2-piperidino-ethyl/-dibenzo [d,g] [1, 3, 6] dioxazocine hydrochloride) may exist in solution in at least two distinct conformations, unlike other tricyclic or non-tricyclic compounds having antimuscarinergic activity. One of these conformations possessing an asymmetric, twisted central hetero-ring confined between two phenyl rings is probably the energetically more stable form, while the other having a butterfly-like structure, with mirror symmetry-related phenyl rings as in phenothiazines seems to be more suitable for receptor binding. The importance of the hydrophobic pocket at the receptor site was revealed by the good correlation of the calculated and measured hydrophobic parameters to the muscarinic activity of these newly synthesized and other known muscarinergic compounds.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0237-6261
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
143-58
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Structure-activity relationships of new muscarinergic dibenzodioxazocines.
pubmed:affiliation
CHINOIN Pharmaceutical and Chemical Works Co., Ltd., Budapest, Hungary
pubmed:publicationType
Journal Article, Comparative Study, In Vitro