Linked Life Data

2514396

Source:http://linkedlifedata.com/resource/pubmed/id/2514396

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1990-2-21
pubmed:abstractText
Lidocaine at a concentration greater than or equal to 0.1 mM inhibited thyrotropin (TSH) and prolactin (PRL) secretion by perifused acutely dispersed rat adenohypophyseal cells stimulated by 10-100 microM thyrotropin-releasing hormone (TRH) or 30 mM K+. The concentration of lidocaine required for half-maximal inhibition of TSH and PRL secretion was approximately 1 and 0.5 mM, respectively. Maximal lidocaine inhibition of TRH-induced secretion was induced within 15 min and a normal response to these secretagogues returned within 20 min after removal of lidocaine from the perifusion medium. The inhibition of secretion by lidocaine may be caused by blocking depolarization of the cell membrane and depressing intracellular calcium mobilization and calcium influx across the plasma membrane.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0028-3835
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
555-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Lidocaine inhibits dispersed anterior pituitary cell thyrotropin and prolactin secretion induced by thyrotropin-releasing hormone or high medium potassium.
pubmed:affiliation
Department of Medicine Oregon Health Sciences University, Portland.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.