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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6 Pt 2
|
| pubmed:dateCreated |
1990-2-2
|
| pubmed:abstractText |
The role of endothelium in the vasodilation of third order arterioles of cremaster muscle to a variety of vasoactive agents was investigated in pentobarbital-anesthetized rats. Changes in diameter to topical administration of agents were measured with image shearing, before and after mercury light/sodium fluorescein (light/dye) treatment of a 50- to 100-microns segment of the arteriole under study and were recorded with video microscopy. Before light/dye treatment, arachidonic acid (10(-5) M), prostaglandin E2 (5 x 10(-6) M), A23187 (2 x 10(-6) M), acetylcholine (10(-5) M), and adenosine (10(-4) M) elicited dilation between 75 and 106% of basal diameter. After light/dye treatment, dilations to arachidonic acid, A23187, and acetylcholine were completely eliminated; however, the responses to prostaglandin E2 and adenosine were not altered. These results indicate that light/dye treatment interferes with the production of or response to prostaglandins as well as other endothelial mediators, like endothelium-derived relaxing factor (EDRF). In a second series of experiments, bradykinin, in concentrations of 10(-9), 10(-8), and 10(-7) M elicited dose-dependent dilations, which were partially inhibited by indomethacin and completely abolished after additional light/dye treatment. Dilation of arterioles to adenosine was maintained throughout these experiments. These data suggest that vasodilation to bradykinin is mediated partly via prostaglandin production and partly via other endothelium-derived factor(s).
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Bradykinin,
http://linkedlifedata.com/resource/pubmed/chemical/Calcimycin,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Indomethacin,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0002-9513
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
257
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
H1966-70
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2513732-Acetylcholine,
pubmed-meshheading:2513732-Adenosine,
pubmed-meshheading:2513732-Animals,
pubmed-meshheading:2513732-Arachidonic Acid,
pubmed-meshheading:2513732-Arachidonic Acids,
pubmed-meshheading:2513732-Arteries,
pubmed-meshheading:2513732-Arterioles,
pubmed-meshheading:2513732-Blood Pressure,
pubmed-meshheading:2513732-Bradykinin,
pubmed-meshheading:2513732-Calcimycin,
pubmed-meshheading:2513732-Dinoprostone,
pubmed-meshheading:2513732-Dose-Response Relationship, Drug,
pubmed-meshheading:2513732-Endothelium,
pubmed-meshheading:2513732-Indomethacin,
pubmed-meshheading:2513732-Male,
pubmed-meshheading:2513732-Muscle, Smooth, Vascular,
pubmed-meshheading:2513732-Nitric Oxide,
pubmed-meshheading:2513732-Rats,
pubmed-meshheading:2513732-Rats, Inbred Strains,
pubmed-meshheading:2513732-Vasodilation
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Endothelial impairment inhibits prostaglandin and EDRF-mediated arteriolar dilation in vivo.
|
| pubmed:affiliation |
Department of Physiology, New York Medical College, Valhalla 10595.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|