| pubmed-article:2511839 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2511839 | lifeskim:mentions | umls-concept:C0006684 | lld:lifeskim |
| pubmed-article:2511839 | lifeskim:mentions | umls-concept:C1801960 | lld:lifeskim |
| pubmed-article:2511839 | lifeskim:mentions | umls-concept:C0022022 | lld:lifeskim |
| pubmed-article:2511839 | lifeskim:mentions | umls-concept:C0032821 | lld:lifeskim |
| pubmed-article:2511839 | lifeskim:mentions | umls-concept:C0032824 | lld:lifeskim |
| pubmed-article:2511839 | lifeskim:mentions | umls-concept:C0042287 | lld:lifeskim |
| pubmed-article:2511839 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2511839 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:2511839 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:2511839 | lifeskim:mentions | umls-concept:C1140999 | lld:lifeskim |
| pubmed-article:2511839 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2511839 | pubmed:dateCreated | 1989-12-28 | lld:pubmed |
| pubmed-article:2511839 | pubmed:abstractText | The effects of a potassium (K+) channel opener BRL34915 and a specific K+ ionophore valinomycin on vasoconstriction induced by endothelin (ET) were compared with those of calcium (Ca2+) channel blockers, nicardipine and verapamil, using helical strips from rat thoracic aorta. ET induced potent and persistent contraction in control solution and similar but smaller contraction in Ca2+-free solution. BRL34915 and valinomycin inhibited the ET-induced contraction dose-dependently in control solution, but not in Ca2+-free solution. The ET-induced contraction was also inhibited by nicardipine and verapamil, though less strongly. On the other hand, high K+ (35 mM)-induced vasoconstriction was strongly inhibited by nicardipine and verapamil, but not by BRL34915 or valinomycin. These results support the idea that the extracellular Ca2+-dependent component of the ET-induced contraction may be mediated by Ca2+ influx by a route other than voltage-dependent Ca2+-channels. | lld:pubmed |
| pubmed-article:2511839 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2511839 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2511839 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2511839 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2511839 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2511839 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:2511839 | pubmed:author | pubmed-author:KimSS | lld:pubmed |
| pubmed-article:2511839 | pubmed:author | pubmed-author:MiyashitaYY | lld:pubmed |
| pubmed-article:2511839 | pubmed:author | pubmed-author:KonKK | lld:pubmed |
| pubmed-article:2511839 | pubmed:author | pubmed-author:MorimotoSS | lld:pubmed |
| pubmed-article:2511839 | pubmed:author | pubmed-author:OgiharaTT | lld:pubmed |
| pubmed-article:2511839 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2511839 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2511839 | pubmed:volume | 164 | lld:pubmed |
| pubmed-article:2511839 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2511839 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2511839 | pubmed:pagination | 1003-8 | lld:pubmed |
| pubmed-article:2511839 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2511839 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2511839 | pubmed:articleTitle | Comparison of effects of a potassium channel opener BRL34915, a specific potassium ionophore valinomycin and calcium channel blockers on endothelin-induced vascular contraction. | lld:pubmed |
| pubmed-article:2511839 | pubmed:affiliation | Department of Geriatric Medicine, Osaka University Medical School, Japan. | lld:pubmed |
| pubmed-article:2511839 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2511839 | pubmed:publicationType | In Vitro | lld:pubmed |
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