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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1989-12-28
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pubmed:abstractText |
The effects of a potassium (K+) channel opener BRL34915 and a specific K+ ionophore valinomycin on vasoconstriction induced by endothelin (ET) were compared with those of calcium (Ca2+) channel blockers, nicardipine and verapamil, using helical strips from rat thoracic aorta. ET induced potent and persistent contraction in control solution and similar but smaller contraction in Ca2+-free solution. BRL34915 and valinomycin inhibited the ET-induced contraction dose-dependently in control solution, but not in Ca2+-free solution. The ET-induced contraction was also inhibited by nicardipine and verapamil, though less strongly. On the other hand, high K+ (35 mM)-induced vasoconstriction was strongly inhibited by nicardipine and verapamil, but not by BRL34915 or valinomycin. These results support the idea that the extracellular Ca2+-dependent component of the ET-induced contraction may be mediated by Ca2+ influx by a route other than voltage-dependent Ca2+-channels.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzopyrans,
http://linkedlifedata.com/resource/pubmed/chemical/Cromakalim,
http://linkedlifedata.com/resource/pubmed/chemical/Egtazic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelins,
http://linkedlifedata.com/resource/pubmed/chemical/Nicardipine,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles,
http://linkedlifedata.com/resource/pubmed/chemical/Valinomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Verapamil
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
164
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1003-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2511839-Animals,
pubmed-meshheading:2511839-Aorta, Thoracic,
pubmed-meshheading:2511839-Benzopyrans,
pubmed-meshheading:2511839-Cromakalim,
pubmed-meshheading:2511839-Egtazic Acid,
pubmed-meshheading:2511839-Endothelins,
pubmed-meshheading:2511839-Endothelium, Vascular,
pubmed-meshheading:2511839-Kinetics,
pubmed-meshheading:2511839-Muscle, Smooth, Vascular,
pubmed-meshheading:2511839-Nicardipine,
pubmed-meshheading:2511839-Peptides,
pubmed-meshheading:2511839-Potassium,
pubmed-meshheading:2511839-Potassium Channels,
pubmed-meshheading:2511839-Pyrroles,
pubmed-meshheading:2511839-Rats,
pubmed-meshheading:2511839-Rats, Inbred Strains,
pubmed-meshheading:2511839-Valinomycin,
pubmed-meshheading:2511839-Vasoconstriction,
pubmed-meshheading:2511839-Vasodilator Agents,
pubmed-meshheading:2511839-Verapamil
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pubmed:year |
1989
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pubmed:articleTitle |
Comparison of effects of a potassium channel opener BRL34915, a specific potassium ionophore valinomycin and calcium channel blockers on endothelin-induced vascular contraction.
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pubmed:affiliation |
Department of Geriatric Medicine, Osaka University Medical School, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro
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