Linked Life Data

2511246

Source:http://linkedlifedata.com/resource/pubmed/id/2511246

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1990-1-5
pubmed:abstractText
The generation of lamin B autoantibodies was examined in a patient with SLE. Lamin B autoantibodies in this individual's serum were almost entirely IgG1 lambda at the onset of the autoimmune response. There was no evidence of IgM to IgG class switching, and no apparent diversification of the autoantibody response over the next 2 yr. The kappa/lambda L chain ratio of the lamin B autoantibodies was 0.13 by ELISA, with a kappa/lambda ratio of 0.70 for the patient's total IgG. In contrast, anti-histone autoantibodies in the patient's serum contained primarily kappa L chain. The kappa/lambda L chain ratios of lamin B autoantibodies from sera of four other patients with SLE were also consistent with restricted heterogeneity of lamin autoantibodies. In two, lambda L chain predominated, and in two others, the lamin B autoantibodies contained predominantly kappa L chains. The restricted heterogeneity of lamin B autoantibodies could be related to targeting of a single immunodominant autoepitope, to the existence of a particular L chain gene or genes that preferentially undergo somatic mutation, leading to the production of lamin B reactive clones, or to a combination of both mechanisms.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
143
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3614-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Preferential use of lambda L chain in lamin B autoantibodies.
pubmed:affiliation
Laboratory of Cell Biology, Rockefeller University, New York 10021.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't