Linked Life Data

2511133

Source:http://linkedlifedata.com/resource/pubmed/id/2511133

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1990-1-11
pubmed:abstractText
To test whether changes in carbohydrate metabolism influence anterior pituitary function, iv TRH tests (25 micrograms TRH) were carried out on three different occasions in 6 normal subjects. On one of these occasions TRH was administered during normoglycemia (blood glucose level 4.5 mmol/l - on the other, during hyperglycemia (10 mmol/l) - and on the third, during hypoglycemia (3 mmol/l). Hypoglycemia reduced the TRH-elicited TSH response significantly (19 +/- 6%), but failed to affect the corresponding PRL response. Hyperglycemia left both the TSH and PRL responses to TRH unaffected. These results imply that thyrotrophs and lactotrophs react differently to changes in carbohydrate metabolism. Thyrotrophs - in contrast to lactotrophs - seem to require a certain minimal glucose delivery to function normally. Glucose excess does not change the reactivity of these pituitary cells significantly.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0018-5043
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
498-501
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Hormone release from thyrotrophs and lactotrophs during hypo- and hyperglycemia.
pubmed:affiliation
Department of Internal Medicine II, Södersjukhuset, Stockholm, Sweden.
pubmed:publicationType
Journal Article