Linked Life Data

2510562

Source:http://linkedlifedata.com/resource/pubmed/id/2510562

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-12-19
pubmed:abstractText
Reversal of benzodiazepine-induced sedation by flumazenil has been reported to produce no or minor hemodynamic alterations although some adverse responses have been observed. To better delineate circulatory and adrenergic modifications induced by flumazenil, 20 consenting patients scheduled for short orthopedic procedures were included in a double blind controlled study. Anesthesia consisted in flunitrazepam (30 to 40 micrograms.kg-1) plus halothane (0.5 vol. % in N2O-O2, 60-40 vol. %) and alfentanil. At the end of surgery, patients received 15 minutes after discontinuation of halothane and N2O, either flumazenil (1 mg) or placebo according th randomization. Heart rate and blood pressure were obtained before reversal and repeatedly for 30 minutes following flumazenil or placebo. Level of consciousness was also assessed and blood samples were withdrawn for subsequent determination of plasma levels of norepinephrine. Flumazenil administration induced in all cases an immediate and total reversion of sedation while recovery was slow in the placebo group. No significant changes in heart rate and blood pressure values were found in both groups. By contrast, plasma levels of norepinephrine were significantly increased in all patients. It is concluded that reversal of benzodiazepine-induced sedation or anesthesia is not associated with significant variations of usual hemodynamic or adrenergic responses.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0750-7658
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
311-5
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
[Hemodynamic and adrenergic effects of flumazenil after general anesthesia with flunitrazepam].
pubmed:affiliation
Département d'Anesthésie-Réanimation, Hôpital Bichat, Paris.
pubmed:publicationType
Journal Article, Clinical Trial, English Abstract, Randomized Controlled Trial