Linked Life Data

2510290

Source:http://linkedlifedata.com/resource/pubmed/id/2510290

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-11-29
pubmed:abstractText
Histamine was shown to suppress the in vitro generation of secondary syngeneic tumour-specific Ly-2+, L3T4- cytotoxic T cells from Ly-2+, L3T4- precursor cells. The sensitivity of the spleen cells from P815X2 mastocytoma-bearing DBA/2 mice to histamine-induced suppression changed during tumour progression; by the time of cytotoxic peak reaction (between days 12 and 16 after P815X2 inoculation), the spleen cells were more resistant to histamine than the spleen cells obtained from mice a few days before or a few days after maximal cytotoxicity. Histamine had no effect on the effector function of in-vitro-generated cytotoxicity. The results suggest histamine-induced modulation of cytotoxic T-cell reactions in P815X2-bearing mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0300-9475
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
449-55
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Immune response against P815X2 mastocytoma growing in syngeneic DBA/2 mice. VI. Histamine-induced suppression of in vitro generation of tumour-specific cytotoxic T cells.
pubmed:affiliation
Department of Clinical Microbiology, University of Kuopio, Finland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't