Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1989-12-11
pubmed:abstractText
Pravastatin sodium was administered orally to cynomolgus monkeys at dosage levels of 50, 100, 200 and 400 mg/kg/day for 5 successive weeks. Five animals of 200 mg/kg and 400 mg/kg dose groups were sacrificed during the study period, because these animals deteriorated in general condition and/or showed remarkable changes in serum biochemical examination. Pathological examination revealed hepatic and/or renal disturbance in these animals. These changes are thought to be the cause of deterioration of general condition or changes in serum biochemical examination. All other animals were terminated at the end of the study period. In the animals of the 100 mg/kg dose group, only one animal showed hepatic and renal disorder similar in nature to the changes in the animals sacrificed during the study period. No animals in the 50 mg/kg dose group showed toxic findings in any examination.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0388-1350
pubmed:author
pubmed:issnType
Print
pubmed:volume
14 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
57-83
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:2509725-Administration, Oral, pubmed-meshheading:2509725-Animals, pubmed-meshheading:2509725-Body Weight, pubmed-meshheading:2509725-Cholesterol, pubmed-meshheading:2509725-Diarrhea, pubmed-meshheading:2509725-Dose-Response Relationship, Drug, pubmed-meshheading:2509725-Female, pubmed-meshheading:2509725-Hematologic Tests, pubmed-meshheading:2509725-Heptanoic Acids, pubmed-meshheading:2509725-Hypolipidemic Agents, pubmed-meshheading:2509725-Kidney Function Tests, pubmed-meshheading:2509725-Liver Function Tests, pubmed-meshheading:2509725-Macaca fascicularis, pubmed-meshheading:2509725-Male, pubmed-meshheading:2509725-Naphthalenes, pubmed-meshheading:2509725-Organ Size, pubmed-meshheading:2509725-Pravastatin, pubmed-meshheading:2509725-Time Factors, pubmed-meshheading:2509725-Urine
pubmed:year
1989
pubmed:articleTitle
Subacute toxicological study in monkeys treated orally with pravastatin sodium for 5 weeks.
pubmed:affiliation
Laboratory of Animal Science and Toxicology Laboratories, Sankyo Co., Ltd., Japan.
pubmed:publicationType
Journal Article