| pubmed-article:2509118 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2509118 | lifeskim:mentions | umls-concept:C0031809 | lld:lifeskim |
| pubmed-article:2509118 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:2509118 | lifeskim:mentions | umls-concept:C0025926 | lld:lifeskim |
| pubmed-article:2509118 | lifeskim:mentions | umls-concept:C1513867 | lld:lifeskim |
| pubmed-article:2509118 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:2509118 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:2509118 | lifeskim:mentions | umls-concept:C0035253 | lld:lifeskim |
| pubmed-article:2509118 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2509118 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:2509118 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:2509118 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:2509118 | pubmed:dateCreated | 1989-12-15 | lld:pubmed |
| pubmed-article:2509118 | pubmed:abstractText | Percoll fractionation of NZB/NZW F1 mouse B cells revealed an increased ratio of low-density fraction ('activated' B cell fraction) and a decreased ratio of high-density fraction ('resting' B cell fraction), in comparison to normal mouse B cells. Resting B cells of B/W F1 mice were hyperresponsive to interleukin-4 (IL-4), with increased proliferation and IgG anti-DNA antibody production, in comparison to normal mice. The hyper-responses of resting B cells from NZB/NZW F1 mice to IL-4 were affected with dose dependency by interferon-gamma (INF-gamma); specifically, cell proliferation and anti-nuclear antibody production were suppressed in the presence of IFN-gamma. This suppressor action of IFN-gamma was most noticeable when it was added to the culture system simultaneously with IL-4. These findings suggested that the abnormally activated state of NZB/NZW F1 mice B cells can be attenuated by the action of IFN-gamma on resting B cells. | lld:pubmed |
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| pubmed-article:2509118 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2509118 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2509118 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2509118 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2509118 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2509118 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:2509118 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:2509118 | pubmed:author | pubmed-author:HamadaKK | lld:pubmed |
| pubmed-article:2509118 | pubmed:author | pubmed-author:HoriuchiAA | lld:pubmed |
| pubmed-article:2509118 | pubmed:author | pubmed-author:MinodaMM | lld:pubmed |
| pubmed-article:2509118 | pubmed:author | pubmed-author:FunauchiMM | lld:pubmed |
| pubmed-article:2509118 | pubmed:author | pubmed-author:SugishimaHH | lld:pubmed |
| pubmed-article:2509118 | pubmed:author | pubmed-author:HigashikawaMM | lld:pubmed |
| pubmed-article:2509118 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2509118 | pubmed:volume | 78 | lld:pubmed |
| pubmed-article:2509118 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2509118 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2509118 | pubmed:pagination | 115-9 | lld:pubmed |
| pubmed-article:2509118 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:2509118 | pubmed:meshHeading | pubmed-meshheading:2509118-... | lld:pubmed |
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| pubmed-article:2509118 | pubmed:meshHeading | pubmed-meshheading:2509118-... | lld:pubmed |
| pubmed-article:2509118 | pubmed:meshHeading | pubmed-meshheading:2509118-... | lld:pubmed |
| pubmed-article:2509118 | pubmed:meshHeading | pubmed-meshheading:2509118-... | lld:pubmed |
| pubmed-article:2509118 | pubmed:meshHeading | pubmed-meshheading:2509118-... | lld:pubmed |
| pubmed-article:2509118 | pubmed:meshHeading | pubmed-meshheading:2509118-... | lld:pubmed |
| pubmed-article:2509118 | pubmed:meshHeading | pubmed-meshheading:2509118-... | lld:pubmed |
| pubmed-article:2509118 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2509118 | pubmed:articleTitle | Examination of the inhibitory effects of interferon-gamma on interleukin-4-induced stimulation of resting B cells from NZB/NZW F1 mice. | lld:pubmed |
| pubmed-article:2509118 | pubmed:affiliation | Third Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan. | lld:pubmed |
| pubmed-article:2509118 | pubmed:publicationType | Journal Article | lld:pubmed |
