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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1989-12-15
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pubmed:abstractText |
Percoll fractionation of NZB/NZW F1 mouse B cells revealed an increased ratio of low-density fraction ('activated' B cell fraction) and a decreased ratio of high-density fraction ('resting' B cell fraction), in comparison to normal mouse B cells. Resting B cells of B/W F1 mice were hyperresponsive to interleukin-4 (IL-4), with increased proliferation and IgG anti-DNA antibody production, in comparison to normal mice. The hyper-responses of resting B cells from NZB/NZW F1 mice to IL-4 were affected with dose dependency by interferon-gamma (INF-gamma); specifically, cell proliferation and anti-nuclear antibody production were suppressed in the presence of IFN-gamma. This suppressor action of IFN-gamma was most noticeable when it was added to the culture system simultaneously with IL-4. These findings suggested that the abnormally activated state of NZB/NZW F1 mice B cells can be attenuated by the action of IFN-gamma on resting B cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-2419430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-2955050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-2961813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-2966762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-2967332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-3097125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-3100961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-3107127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-3114409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-3121224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-3157753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-3297106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-3495799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-3873071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-3890479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-3933529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-4883742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-561128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-6195895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-6310596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-6406639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-6429546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-6429547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-6795304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-6802927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-6813857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2509118-6818554
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
115-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:2509118-Animals,
pubmed-meshheading:2509118-B-Lymphocytes,
pubmed-meshheading:2509118-Cell Extracts,
pubmed-meshheading:2509118-Cells, Cultured,
pubmed-meshheading:2509118-Female,
pubmed-meshheading:2509118-Interferon-gamma,
pubmed-meshheading:2509118-Interleukin-4,
pubmed-meshheading:2509118-Lymphocyte Activation,
pubmed-meshheading:2509118-Mice,
pubmed-meshheading:2509118-Recombinant Proteins
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pubmed:year |
1989
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pubmed:articleTitle |
Examination of the inhibitory effects of interferon-gamma on interleukin-4-induced stimulation of resting B cells from NZB/NZW F1 mice.
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pubmed:affiliation |
Third Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan.
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pubmed:publicationType |
Journal Article
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