Linked Life Data

2509020

Source:http://linkedlifedata.com/resource/pubmed/id/2509020

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1989-12-12
pubmed:abstractText
Osteoclastic bone resorption can be induced within the auditory bulla of the Mongolian gerbil by minute increases in air pressure. The objective of this study was to determine the rate at which osteoclasts are induced in areas of resorption and to compare the rate of osteoblast recruitment. Stainless steel tubes were implanted into the middle ears of 31 male gerbils through which a static pressure of 10 mm Hg above atmospheric was applied. The animals were killed at intervals (0, 1, 2, 4, 6, and 8 days) and the ventral wall of the bulla was studied histomorphometrically. The osteoclast area and osteoclast number were measured along the inner surface of the bone of the bulla; the activity of osteoblasts of the outer surface was also estimated. A significant increase in osteoclasts was found over time (P less than 0.0001). There was no significant increase in osteoclasts at 1 day (P = 0.5) but at 2, 4, 6, and 8 days there was a significant increase (P less than 0.03). Osteoblast activity on the outside of the bulla wall paralleled osteoclast activity. In this quantifiable, experimental system, a localized modeling process may be induced within 2 days without the confounding elements of localized trauma or inflammation inherent in other models of localized bone remodeling.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0171-967X
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
318-23
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Rapid induction of localized bone resorption in the auditory bulla of the Mongolian gerbil, Meriones unguiculatus, by increased air pressure.
pubmed:affiliation
University of California, Davis School of Medicine.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.