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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1989-11-15
|
| pubmed:abstractText |
Squirrel monkeys were trained to emit one response after IV administration of l-nicotine (0.4 or 0.2 mumol/kg) and a different response after IV administration of saline. After stable discriminative performances were established, subjects were tested with cumulative doses of l-nicotine (0.02-2.2 mumol/kg), d-nicotine (0.02-19.7 mumol/kg), l-nornicotine (0.2-12.0 mumol/kg), l-cotinine (56.8-567.5 mumol/kg), and dl-anabasine (0.6-19.7 mumol/kg). All of the drugs produced dose-related increases in the percentage of drug-appropriate responses emitted, from predominantly saline-appropriate responses after low doses, to predominantly drug-appropriate responses at the highest doses studied. Relative potency comparisons indicated that l-nicotine was 28 times more potent than d-nicotine, 29 times more potent than l-nornicotine, and approximately 2000 times more potent than l-cotinine. Each of the drugs also produced decreases in rates of responding, with potency order similar to that obtained for the discriminative effects. The effects of l-cotinine may be attributed to trace amounts of l-nicotine, which existed within the l-cotinine. The effects of dl-anabasine were lethal in one subject and were consequently not studied in the other subjects.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0033-3158
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
99
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
208-12
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2508155-Anabasine,
pubmed-meshheading:2508155-Animals,
pubmed-meshheading:2508155-Conditioning, Operant,
pubmed-meshheading:2508155-Cotinine,
pubmed-meshheading:2508155-Discrimination (Psychology),
pubmed-meshheading:2508155-Dose-Response Relationship, Drug,
pubmed-meshheading:2508155-Injections, Intravenous,
pubmed-meshheading:2508155-Male,
pubmed-meshheading:2508155-Nicotine,
pubmed-meshheading:2508155-Reinforcement Schedule,
pubmed-meshheading:2508155-Saimiri,
pubmed-meshheading:2508155-Stereoisomerism
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Discriminative stimulus effects of intravenous l-nicotine and nicotine analogs or metabolites in squirrel monkeys.
|
| pubmed:affiliation |
Preclinical Pharmacology Branch, NIDA Addiction Research Center, Baltimore, MD 21224.
|
| pubmed:publicationType |
Journal Article
|