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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1989-10-25
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pubmed:abstractText |
1. The uptake of neutral amino acids from the blood into the cells of the choroid plexus was studied by means of the rapid (less than 40 s) single-circulation paired-tracer dilution technique in the isolated perfused choroid plexus of the sheep. 2. The study provides the first direct evidence for the carrier-mediated entry of neutral amino acids from blood into the cells of the choroid plexus. 3. In the terms of Christensen's classification the presence of L-amino acid carrier systems for large neutral amino acids with bulky side chains has been demonstrated. 4. No measurable uptake of [14C]methyl amino isobutyric acid ([14C]MeAIB) during a single passage through the choroid plexus circulation was demonstrated which indicates the probable absence of a significant 'A' transport system. 5. The uptake of small neutral amino acids such as glycine and L-alanine was shown to be carrier-mediated. Results suggest that these amino acids are mainly transported by the glycine and ASC carrier systems, respectively. 6. The results suggest that there is a similarity between the transport systems for neutral amino acids on the blood side of both the blood-brain barrier and blood-cerebrospinal fluid barrier, the exception being for the presence of a glycine carrier on the blood side of the choroid plexus.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2506339-1251917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2506339-13121225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2506339-13268666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2506339-3017689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2506339-3083044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2506339-338318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2506339-3935272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2506339-3940873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2506339-4020688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2506339-4538348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2506339-4546407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2506339-5025127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2506339-5038848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2506339-5092631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2506339-6028247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2506339-7108514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2506339-833586
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-3751
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
408
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
31-43
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pubmed:dateRevised |
2010-8-25
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pubmed:meshHeading |
pubmed-meshheading:2506339-Amino Acids,
pubmed-meshheading:2506339-Aminoisobutyric Acids,
pubmed-meshheading:2506339-Animals,
pubmed-meshheading:2506339-Binding, Competitive,
pubmed-meshheading:2506339-Biological Transport,
pubmed-meshheading:2506339-Cerebrospinal Fluid,
pubmed-meshheading:2506339-Choroid Plexus,
pubmed-meshheading:2506339-Female,
pubmed-meshheading:2506339-Glycine,
pubmed-meshheading:2506339-Leucine,
pubmed-meshheading:2506339-Male,
pubmed-meshheading:2506339-Mannitol,
pubmed-meshheading:2506339-Phenylalanine,
pubmed-meshheading:2506339-Sheep
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pubmed:year |
1989
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pubmed:articleTitle |
Neutral amino acid uptake by the isolated perfused sheep choroid plexus.
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pubmed:affiliation |
Sherrington School of Physiology, United Medical School of Guy's Hospitals, London.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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