|
rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
6
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|
pubmed:dateCreated |
1989-10-10
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|
pubmed:abstractText |
Dermorphin- growth hormone releasing factor (GRF) hybrid peptides (Y-Tyr-D-Ala-Xaa-Gly-Tyr-Pro-Ser-NH2) were synthesized and tested for opioid activity and their ability to stimulate growth hormone (GH) secretion. The substitution of Phe3 for Asp and Glu in dermorphin or its N-terminal acetylation produced peptides with no affinity for opioid receptors but significant, even if low, GRF-like activity.
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|
pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Jun
|
|
pubmed:issn |
0004-4172
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
39
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
639-41
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|
pubmed:dateRevised |
2008-11-24
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pubmed:meshHeading |
pubmed-meshheading:2505781-Animals,
pubmed-meshheading:2505781-Brain Chemistry,
pubmed-meshheading:2505781-Chemistry, Physical,
pubmed-meshheading:2505781-Dose-Response Relationship, Drug,
pubmed-meshheading:2505781-Growth Hormone,
pubmed-meshheading:2505781-Growth Hormone-Releasing Hormone,
pubmed-meshheading:2505781-Guinea Pigs,
pubmed-meshheading:2505781-Male,
pubmed-meshheading:2505781-Oligopeptides,
pubmed-meshheading:2505781-Opioid Peptides,
pubmed-meshheading:2505781-Physicochemical Phenomena,
pubmed-meshheading:2505781-Rats
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|
pubmed:year |
1989
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|
pubmed:articleTitle |
Synthesis and activity of dermorphin-growth hormone releasing factor hybrid peptides.
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|
pubmed:affiliation |
Department of Pharmaceutical Sciences, University of Ferrara, Italy.
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pubmed:publicationType |
Journal Article,
In Vitro
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