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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
740
|
| pubmed:dateCreated |
1989-9-28
|
| pubmed:abstractText |
The results of radiation treatment of nasopharyngeal carcinoma (NPC) have recently been improved, but the prognosis remains relatively poor in cases with cranial nerve (CN) involvement. A total of 109 cases with histologically-proven NPC and cranial nerve involvement treated during 1979-1985 were reviewed and analysed. Definitive radiotherapy (RT) was given to patients with a high upper margin of the RT field at 2.5 cm above the base of the skull to a total dose of 70.2 Gy/39 fractions/8 weeks, with two applications of intranasopharyngeal brachytherapy. There were 37 cases (34%) in Group I (upward invasion only) and 72 cases (66%) in Group II (bidirectional invasion). Abducens, trigeminal, oculomotor and facial were the commonly involved nerves. Headache was the major symptom at diagnosis and was present in 82.6% of the patients, significantly higher than in general NPC cases (p less than 0.005). Fifty per cent (31/62) achieved complete response to definitive RT, but it did not correlate well with survival rate. The residual neurological deficit of each CN ranged from 31 to 57%. The actuarial 5-year survival rates of Groups I and II were similar in spite of neck lymph node metastasis in Group II (33% (I) compared with 24% (II); p greater than 0.05). Cases with single CN deficit did not show better results than those with multiple CN involvements. Five-year survivors were seen only in those who received a complete course of definitive RT.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0007-1285
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
62
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
739-43
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2504432-Adult,
pubmed-meshheading:2504432-Aged,
pubmed-meshheading:2504432-Carcinoma,
pubmed-meshheading:2504432-Cranial Nerve Diseases,
pubmed-meshheading:2504432-Female,
pubmed-meshheading:2504432-Humans,
pubmed-meshheading:2504432-Male,
pubmed-meshheading:2504432-Middle Aged,
pubmed-meshheading:2504432-Nasopharyngeal Neoplasms,
pubmed-meshheading:2504432-Radiotherapy, High-Energy
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Clinical significance of cranial nerve deficit in the therapy of nasopharyngeal carcinoma.
|
| pubmed:affiliation |
Department of Radiation Oncology, Chang Gung Memorial Hospital, Taipei, Taiwan.
|
| pubmed:publicationType |
Journal Article
|