Linked Life Data

2503955

Source:http://linkedlifedata.com/resource/pubmed/id/2503955

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-9-19
pubmed:abstractText
The immune status, the level of expression of class II HLA histocompatibility antigens in the peripheral blood cells, and the effects on this antigen expression of alpha- and gamma-interferons have been examined in 21 patients with psoriatic arthropathy. Examinations of the immune status have revealed reduced levels of T-lymphocytes, of active E-RFC, of cells forming rosettes with autologous red cells, and an increased count of 0-lymphocytes. The level of class II antigen expression in monocytes, in total lymphocyte population, and in the fraction enriched for B-lymphocytes is much reduced in all the patients suffering from psoriatic arthropathy. The level of these antigens' expression in T-lymphocytes is increased in 2/3 of patients and unchanged in the rest. Intranasal alpha-interferon increased class II antigen expression in the peripheral blood monocytes of patients, whereas gamma-interferon induced no such effect. The stimulating effect of alpha-interferon on the patients' monocytes has been much less manifest than on normal donor monocytes. The antigen expression in the patients' blood lymphocytes exposed to alpha- and gamma-interferons has been virtually the same.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0042-4609
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
10-4
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
[Expression of the class II antigens of the major histocompatibility complex on the blood cells of psoriasis patients and its alteration under the influence of interferon preparations].
pubmed:publicationType
Journal Article, Comparative Study, English Abstract