| pubmed-article:2502629 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2502629 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:2502629 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:2502629 | lifeskim:mentions | umls-concept:C0027950 | lld:lifeskim |
| pubmed-article:2502629 | lifeskim:mentions | umls-concept:C0002792 | lld:lifeskim |
| pubmed-article:2502629 | lifeskim:mentions | umls-concept:C0003691 | lld:lifeskim |
| pubmed-article:2502629 | lifeskim:mentions | umls-concept:C0003693 | lld:lifeskim |
| pubmed-article:2502629 | lifeskim:mentions | umls-concept:C0020314 | lld:lifeskim |
| pubmed-article:2502629 | lifeskim:mentions | umls-concept:C0033551 | lld:lifeskim |
| pubmed-article:2502629 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2502629 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:2502629 | lifeskim:mentions | umls-concept:C0205549 | lld:lifeskim |
| pubmed-article:2502629 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:2502629 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:2502629 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:2502629 | pubmed:dateCreated | 1989-9-7 | lld:pubmed |
| pubmed-article:2502629 | pubmed:abstractText | The synthesis of a series of novel substituted hydroxamates has been described along with their profile of inhibitory activity against 5-lipoxygenase, 12-lipoxygenase, and cyclooxygenase enzymes. The structure--activity relationship suggests that future molecules could be designed to specifically inhibit one or more of these enzymes since there were definite differences in structure--activity relationships for these different enzymes. A representative number of these compounds have been tested in vivo and found to possess potent oral activity in a systemic anaphylaxis model mediated by leukotrienes and topical activity in an arachidonic acid induced inflammation model. One of these molecules, compound 20, demonstrated that a leukotriene antagonist pharmacophore can be modified such that it contains both antagonist activity and 5-lipoxygenase inhibitory activity. | lld:pubmed |
| pubmed-article:2502629 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2502629 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2502629 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2502629 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2502629 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2502629 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2502629 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2502629 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2502629 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2502629 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2502629 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:2502629 | pubmed:author | pubmed-author:HuangF CFC | lld:pubmed |
| pubmed-article:2502629 | pubmed:author | pubmed-author:ShoupeT STS | lld:pubmed |
| pubmed-article:2502629 | pubmed:author | pubmed-author:LiuC ACA | lld:pubmed |
| pubmed-article:2502629 | pubmed:author | pubmed-author:LeeT DTD | lld:pubmed |
| pubmed-article:2502629 | pubmed:author | pubmed-author:UDAYY | lld:pubmed |
| pubmed-article:2502629 | pubmed:author | pubmed-author:ChanW KWK | lld:pubmed |
| pubmed-article:2502629 | pubmed:author | pubmed-author:SuhJ TJT | lld:pubmed |
| pubmed-article:2502629 | pubmed:author | pubmed-author:GordonR JRJ | lld:pubmed |
| pubmed-article:2502629 | pubmed:author | pubmed-author:SchnapperMM | lld:pubmed |
| pubmed-article:2502629 | pubmed:author | pubmed-author:SonninoP APA | lld:pubmed |
| pubmed-article:2502629 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2502629 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:2502629 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2502629 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:2502629 | pubmed:pagination | 1836-42 | lld:pubmed |
| pubmed-article:2502629 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:2502629 | pubmed:meshHeading | pubmed-meshheading:2502629-... | lld:pubmed |
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| pubmed-article:2502629 | pubmed:meshHeading | pubmed-meshheading:2502629-... | lld:pubmed |
| pubmed-article:2502629 | pubmed:meshHeading | pubmed-meshheading:2502629-... | lld:pubmed |
| pubmed-article:2502629 | pubmed:meshHeading | pubmed-meshheading:2502629-... | lld:pubmed |
| pubmed-article:2502629 | pubmed:meshHeading | pubmed-meshheading:2502629-... | lld:pubmed |
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| pubmed-article:2502629 | pubmed:meshHeading | pubmed-meshheading:2502629-... | lld:pubmed |
| pubmed-article:2502629 | pubmed:meshHeading | pubmed-meshheading:2502629-... | lld:pubmed |
| pubmed-article:2502629 | pubmed:meshHeading | pubmed-meshheading:2502629-... | lld:pubmed |
| pubmed-article:2502629 | pubmed:meshHeading | pubmed-meshheading:2502629-... | lld:pubmed |
| pubmed-article:2502629 | pubmed:meshHeading | pubmed-meshheading:2502629-... | lld:pubmed |
| pubmed-article:2502629 | pubmed:meshHeading | pubmed-meshheading:2502629-... | lld:pubmed |
| pubmed-article:2502629 | pubmed:meshHeading | pubmed-meshheading:2502629-... | lld:pubmed |
| pubmed-article:2502629 | pubmed:meshHeading | pubmed-meshheading:2502629-... | lld:pubmed |
| pubmed-article:2502629 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2502629 | pubmed:articleTitle | Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis. | lld:pubmed |
| pubmed-article:2502629 | pubmed:affiliation | Rorer Central Research, Horsham, Pennsylvania 19044. | lld:pubmed |
| pubmed-article:2502629 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2502629 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:2502629 | lld:chembl |
