|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0004359,
umls-concept:C0020517,
umls-concept:C0086597,
umls-concept:C0178539,
umls-concept:C0205263,
umls-concept:C0205349,
umls-concept:C0439851,
umls-concept:C1155266,
umls-concept:C1512658,
umls-concept:C1552596,
umls-concept:C1947931
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1989-8-30
|
|
pubmed:abstractText |
X-irradiated (250 rads) A mice injected with syngeneic trinitrophenylated spleen cells (Syn-TNP-SC) developed syngeneic delayed-type hypersensitivity (Syn-DTH) after footpad challenge with syngeneic concanavalin A-induced lymphoblasts (Syn-Con A blasts), as indicated by footpad swelling and lymph-node proliferation assays. Genetic analysis with different recombinant strains of mouse revealed that the H-2Dd subregion restricts these immunological activities. A small immunogenic entity was isolated from Syn-TNP-SC extract by gel filtration and affinity chromatography with anti-Dd antibody. X-irradiated A mice injected with this antigen also generated inflammatory responses after challenge with Syn-Con A blasts. Analysis of the data obtained from the gel filtration and the affinity chromatography suggest that the Syn-DTH-stimulating antigen is a fragment of the H-2Dd heavy chain with a molecular weight (MW) of 5,000 to 10,000. This fragment does not contain TNP molecules or sugar moieties and neither does it express affinity for antibodies against class II products. Ltk-cells transfected with the H-2Dd gene also induced Syn-DTH in X-irradiated A mice, while the parent cells failed to stimulate such a response. Taken together these findings indicate that the selection process in the thymus is not absolute and T cells recognizing self-major histocompatibility complex (MHC) products do migrate from this organ to the periphery of the immune system. The possible biological significance of these autoreactive cells is discussed.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2502495-2966434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2502495-3091491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2502495-312902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2502495-3280471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2502495-3422511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2502495-3463623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2502495-3833853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2502495-387870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2502495-398326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2502495-4142565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2502495-6056841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2502495-6181513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2502495-6184620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2502495-6230714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2502495-6407984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2502495-6983970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2502495-7058332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2502495-7076287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2502495-7188699
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0019-2805
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
67
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
184-90
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:2502495-Animals,
pubmed-meshheading:2502495-Autoantigens,
pubmed-meshheading:2502495-Female,
pubmed-meshheading:2502495-Genes, MHC Class II,
pubmed-meshheading:2502495-H-2 Antigens,
pubmed-meshheading:2502495-Hypersensitivity, Delayed,
pubmed-meshheading:2502495-Immunologic Deficiency Syndromes,
pubmed-meshheading:2502495-Mice,
pubmed-meshheading:2502495-Mice, Inbred A,
pubmed-meshheading:2502495-Mice, Inbred BALB C,
pubmed-meshheading:2502495-Mice, Mutant Strains,
pubmed-meshheading:2502495-Spleen,
pubmed-meshheading:2502495-T-Lymphocytes,
pubmed-meshheading:2502495-Transfection,
pubmed-meshheading:2502495-Trinitrobenzenes
|
|
pubmed:year |
1989
|
|
pubmed:articleTitle |
Auto-delayed-type hypersensitivity induced in immunodeficient mice with modified self-antigens. V. Cellular autoreactivity directed against self-H-2Dd subregion mediates the inflammatory responses.
|
|
pubmed:affiliation |
Lautenberg Center for General and Tumor Immunology, Hebrew University, Jerusalem, Israel.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
