Linked Life Data

2501776

Source:http://linkedlifedata.com/resource/pubmed/id/2501776

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-8-22
pubmed:abstractText
Esculetin (6,7-dihydroxycoumarin) was tested in isolated guinea-pig tracheal chains from normal and ovalbumin-sensitized animals. The drug showed a concentration-dependent relaxant effect, with an EC50 of 60 microM. Pretreatment with esculetin (30-60 microM) was not able to reduce the contractile response induced by either carbachol (0.1 microM), histamine (10 microM), BaCl2 (10 mM) or K+ (80 mM). Esculetin increased the contraction evoked by PGF2 alpha and by histamine, but reduced A23187-induced contraction. Mepacrine (10 microM), a phospholipase A2 inhibitor, reduced the relaxant effect of the lower esculetin concentrations (3-60 microM). Indomethacin (0.1 microM) increased the relaxation induced by esculetin (3-10 microM). In tracheal chains from ovalbumin-sensitized guinea-pigs, esculetin (60 microM) significantly reduced the duration of the recovery phase after antigen challenge contraction. In conclusion, in our in vitro conditions, this natural coumarin derivative seems to act by interfering with the arachidonic acid cascade.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1043-6618
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
183-92
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Effects of esculetin (6,7-dihydroxycoumarin) on guinea-pig tracheal chains in vitro.
pubmed:affiliation
Department of Pharmacology, University of Padova, Italy.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't