Linked Life Data

2501133

Source:http://linkedlifedata.com/resource/pubmed/id/2501133

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-8-25
pubmed:abstractText
A double-blind study was conducted to examine the effect of enprostil on tetra-gastrin stimulated gastric acid secretion in twelve healthy male volunteers. Each subject underwent four tests in random order on separate days with oral doses of 15, 25, 35 micrograms enprostil and placebo. After measuring basal secretion and gastrin release, tetra-gastrin was injected intramuscularly. Gastric secretion and gastrin release were measured over the next two hours. Enprostil dose-dependently inhibited tetragastrin stimulated gastric secretion volume, acid and pepsin output. There were significant differences in gastric acid secretion inhibition between the 15 and 25 micrograms doses, and the 15 and 35 micrograms doses, but only a slight dose response was seen between the 25 and 35 micrograms doses with no significant difference. Serum gastrin level was not influenced by the administration of enprostil. No side effects attributed to enprostil were observed throughout the study.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0435-1339
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
115-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Inhibitory action of enprostil (4,5-dehydro-16-phenoxy-17,18,19,20-tetranor-PGE2) on tetra-gastrin stimulated acid secretion in human subjects.
pubmed:affiliation
First Department of Internal Medicine, Kyoto University Faculty of Medicine, Japan.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial