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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1989-8-16
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pubmed:abstractText |
We have generated transgenic mouse lines that carry one of three different constructs in which the murine N-myc gene is expressed under the control of the immunoglobulin heavy chain transcriptional enhancer element (E mu-N-myc genes). High-level expression of the E mu-N-myc transgenes occurred in lymphoid tissues; correspondingly, many of these E mu-N-myc lines reproducibly developed pre-B- and B-lymphoid malignancies. The E mu-N-myc transgene also appeared to participate in the generation of a T cell malignancy that developed in one E mu-N-myc mouse. These tumors and cell lines adapted from them expressed exceptionally high levels of the E mu-N-myc transgene; the levels were comparable to those observed in human neuroblastomas with highly amplified N-myc genes. In contrast, all of the E mu-N-myc cell lines had exceptionally low or undetectable levels of the c-myc RNA sequences, consistent with the possibility that high-level N-myc expression can participate in the negative 'cross-regulation' of c-myc gene expression. Our findings demonstrate that deregulated expression of the N-myc gene has potent oncogenic potential within the B-lymphoid lineage despite the fact that the N-myc gene has never been implicated in naturally occurring B-lymphoid malignancies. Our results also are discussed in the context of differential myc gene activity in normal and transformed cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-10872333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-2419762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-2430692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-2457153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-2578321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-2827002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-2828024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-2838049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-2869488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-2997622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-3034500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-3034625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-3082521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-3096089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-3096575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-3258007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-3322939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-3493320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-3510398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-3513190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-3520340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-3840574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-3860871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-3906410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-3930970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-4040214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-4059056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-6091894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-6092962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-6203743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-6296253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-6321164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-6331676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-6409417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-6409418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-6606489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-6611207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-6769117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-6771761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-6772444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-6787590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2501083-6810096
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1121-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2501083-Animals,
pubmed-meshheading:2501083-B-Lymphocytes,
pubmed-meshheading:2501083-Cell Differentiation,
pubmed-meshheading:2501083-Enhancer Elements, Genetic,
pubmed-meshheading:2501083-Female,
pubmed-meshheading:2501083-Gene Expression Regulation,
pubmed-meshheading:2501083-Gene Rearrangement,
pubmed-meshheading:2501083-Genes, Immunoglobulin,
pubmed-meshheading:2501083-Immunoglobulin Heavy Chains,
pubmed-meshheading:2501083-Lymphoma,
pubmed-meshheading:2501083-Male,
pubmed-meshheading:2501083-Mice,
pubmed-meshheading:2501083-Mice, Transgenic,
pubmed-meshheading:2501083-Oncogenes
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pubmed:year |
1989
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pubmed:articleTitle |
IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c-myc expression.
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pubmed:affiliation |
Howard Hughes Medical Institute, New York, NY.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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