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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1989-7-18
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pubmed:abstractText |
Mice injected with monoclonal antibody to the L3T4+ (CD4+) cell membrane surface glycoprotein of T lymphocytes and immunized with antigens of Trypanosoma cruzi had reduced antibody and cell-mediated immune responses to the organism. Mortality in these mice was 100% following challenge with 1.5 x 10(5) trypanosomes, whereas controls had a 50% survival rate, indicating that T-cell activation and viable L3T4+ (CD4+) T lymphocytes are essential for the development of resistance.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2499547-116128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2499547-15275616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2499547-15275617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2499547-16471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2499547-2440690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2499547-2783605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2499547-2885376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2499547-2908229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2499547-2955044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2499547-2972093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2499547-3087879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2499547-3529524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2499547-3935472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2499547-4126757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2499547-4997200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2499547-6195085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2499547-6428245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2499547-818311
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2246-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2499547-Animals,
pubmed-meshheading:2499547-Antibodies, Monoclonal,
pubmed-meshheading:2499547-Antigen-Antibody Reactions,
pubmed-meshheading:2499547-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:2499547-Antigens, Protozoan,
pubmed-meshheading:2499547-Cell Survival,
pubmed-meshheading:2499547-Chagas Disease,
pubmed-meshheading:2499547-Immunity, Innate,
pubmed-meshheading:2499547-Mice,
pubmed-meshheading:2499547-Phenotype,
pubmed-meshheading:2499547-T-Lymphocytes,
pubmed-meshheading:2499547-Trypanosoma cruzi
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pubmed:year |
1989
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pubmed:articleTitle |
Development of resistance to Trypanosoma cruzi in mice depends on a viable population of L3T4+ (CD4+) T lymphocytes.
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pubmed:affiliation |
Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, California 94301.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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