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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1989-7-3
|
| pubmed:abstractText |
To assess the efficacy of low dose praziquantel regimens in comparison with standard 40 mg/kg dosing in the treatment of urinary schistosomiasis, a random allocation dose-finding trial was performed in children and adults from a Schistosoma haematobium endemic region in Coast Province, Kenya. Following an initial screening, 280 individuals with greater than or equal to 50 eggs/10 ml urine were randomly assigned to receive either 10, 20, 30, or 40 mg/kg of the drug in a single oral dose. Two to three months later, cure rates of 26%, 68%, 78%, and 84% were found for the 10, 20, 30, and 40 mg/kg doses, respectively. The results of 10 mg/kg oral dosing were significantly worse than for all other doses in terms of cure rate and of post-treatment prevalence of morbidity. The 40 mg/kg dosing resulted in a significantly higher cure rate than the 20 mg/kg doses; nevertheless, there was no significant difference between 20 mg/kg and 40 mg/kg doses in terms of mean post-treatment intensity of infection or post-treatment prevalence of hematuria or proteinuria. For large-scale control programs, oral 20 mg/kg praziquantel therapy for urinary schistosomiasis may prove as effective as the standard oral 40 mg/kg dosing for control of infection-associated morbidity and reduction of parasite transmission.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0002-9637
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
507-13
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2499203-Adolescent,
pubmed-meshheading:2499203-Adult,
pubmed-meshheading:2499203-Age Factors,
pubmed-meshheading:2499203-Aged,
pubmed-meshheading:2499203-Analysis of Variance,
pubmed-meshheading:2499203-Child,
pubmed-meshheading:2499203-Clinical Trials as Topic,
pubmed-meshheading:2499203-Dose-Response Relationship, Drug,
pubmed-meshheading:2499203-Female,
pubmed-meshheading:2499203-Follow-Up Studies,
pubmed-meshheading:2499203-Hematuria,
pubmed-meshheading:2499203-Humans,
pubmed-meshheading:2499203-Kenya,
pubmed-meshheading:2499203-Male,
pubmed-meshheading:2499203-Middle Aged,
pubmed-meshheading:2499203-Praziquantel,
pubmed-meshheading:2499203-Proteinuria,
pubmed-meshheading:2499203-Random Allocation,
pubmed-meshheading:2499203-Schistosomiasis haematobia
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Dose-finding study for praziquantel therapy of Schistosoma haematobium in Coast Province, Kenya.
|
| pubmed:affiliation |
Case Western Reserve University, Ohio.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|