| pubmed-article:2498776 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2498776 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:2498776 | lifeskim:mentions | umls-concept:C0596790 | lld:lifeskim |
| pubmed-article:2498776 | lifeskim:mentions | umls-concept:C0017661 | lld:lifeskim |
| pubmed-article:2498776 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
| pubmed-article:2498776 | lifeskim:mentions | umls-concept:C0332448 | lld:lifeskim |
| pubmed-article:2498776 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:2498776 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2498776 | pubmed:dateCreated | 1989-7-13 | lld:pubmed |
| pubmed-article:2498776 | pubmed:abstractText | The leucocyte subpopulations in the interstitium and the glomeruli in renal biopsies from 34 patients with IgA nephropathy were analysed using monoclonal antibodies and immunoperoxidase techniques. Monocyte/macrophages and T-cells constituted the predominant infiltrating cell type in the interstitium (278 +/- 24 and 269 +/- 37 cells/mm2 respectively). Few intraglomerular leucocytes were seen, the majority of them belonging to the monocyte/macrophage phenotype (1.1 +/- 0.1 cells/glomerular cross-section). CD4+ lymphocytes predominated among the interstitial and glomerular T-cell populations and the CD4:CD8 ratio was 2.1 +/- 1.1 and 2.4 +/- 1.5 respectively. Only small numbers of NK cells and B cells were found in the interstitium, and almost none in the glomeruli. In contrast, significantly increased numbers of DR-expressing interstitial cells were seen (487 +/- 29/mm2), whereas DR expression by the tubular cells was minimal (37 +/- 6/mm2). Numbers of total leukocytes and T-cells were well correlated with the degree of tubulointerstitial damage and there was a significant correlation between renal functional impairment at the time of biopsy and the numbers of interstitial T cells (P less than 0.05) and CD4+ T cells (P less than 0.01). In contrast, interstitial mononuclear cells did not correlate with subsequent progression of the disease over 2-3 years. However, a more rapid decline of renal function was associated with increased numbers of interstitial B cells. No association was found between intraglomerular cells and degree of renal impairment either at the time of biopsy or in the long term.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:2498776 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2498776 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2498776 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2498776 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2498776 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2498776 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2498776 | pubmed:issn | 0931-0509 | lld:pubmed |
| pubmed-article:2498776 | pubmed:author | pubmed-author:CameronJ SJS | lld:pubmed |
| pubmed-article:2498776 | pubmed:author | pubmed-author:HartleyR BRB | lld:pubmed |
| pubmed-article:2498776 | pubmed:author | pubmed-author:AlexopoulosEE | lld:pubmed |
| pubmed-article:2498776 | pubmed:author | pubmed-author:SeronDD | lld:pubmed |
| pubmed-article:2498776 | pubmed:author | pubmed-author:NolascoFF | lld:pubmed |
| pubmed-article:2498776 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2498776 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:2498776 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2498776 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2498776 | pubmed:pagination | 187-95 | lld:pubmed |
| pubmed-article:2498776 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:2498776 | pubmed:meshHeading | pubmed-meshheading:2498776-... | lld:pubmed |
| pubmed-article:2498776 | pubmed:year | 1989 | lld:pubmed |
| pubmed-article:2498776 | pubmed:articleTitle | The role of interstitial infiltrates in IgA nephropathy: a study with monoclonal antibodies. | lld:pubmed |
| pubmed-article:2498776 | pubmed:affiliation | Renal Unit, Guy's United Medical School, London, UK. | lld:pubmed |
| pubmed-article:2498776 | pubmed:publicationType | Journal Article | lld:pubmed |
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