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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1989-7-13
|
| pubmed:abstractText |
The leucocyte subpopulations in the interstitium and the glomeruli in renal biopsies from 34 patients with IgA nephropathy were analysed using monoclonal antibodies and immunoperoxidase techniques. Monocyte/macrophages and T-cells constituted the predominant infiltrating cell type in the interstitium (278 +/- 24 and 269 +/- 37 cells/mm2 respectively). Few intraglomerular leucocytes were seen, the majority of them belonging to the monocyte/macrophage phenotype (1.1 +/- 0.1 cells/glomerular cross-section). CD4+ lymphocytes predominated among the interstitial and glomerular T-cell populations and the CD4:CD8 ratio was 2.1 +/- 1.1 and 2.4 +/- 1.5 respectively. Only small numbers of NK cells and B cells were found in the interstitium, and almost none in the glomeruli. In contrast, significantly increased numbers of DR-expressing interstitial cells were seen (487 +/- 29/mm2), whereas DR expression by the tubular cells was minimal (37 +/- 6/mm2). Numbers of total leukocytes and T-cells were well correlated with the degree of tubulointerstitial damage and there was a significant correlation between renal functional impairment at the time of biopsy and the numbers of interstitial T cells (P less than 0.05) and CD4+ T cells (P less than 0.01). In contrast, interstitial mononuclear cells did not correlate with subsequent progression of the disease over 2-3 years. However, a more rapid decline of renal function was associated with increased numbers of interstitial B cells. No association was found between intraglomerular cells and degree of renal impairment either at the time of biopsy or in the long term.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0931-0509
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
187-95
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:2498776-Adolescent,
pubmed-meshheading:2498776-Adult,
pubmed-meshheading:2498776-Antibodies, Monoclonal,
pubmed-meshheading:2498776-B-Lymphocytes,
pubmed-meshheading:2498776-Child,
pubmed-meshheading:2498776-Extracellular Space,
pubmed-meshheading:2498776-Female,
pubmed-meshheading:2498776-Glomerular Mesangium,
pubmed-meshheading:2498776-Glomerulonephritis, IGA,
pubmed-meshheading:2498776-HLA-DR Antigens,
pubmed-meshheading:2498776-Humans,
pubmed-meshheading:2498776-Kidney Tubules,
pubmed-meshheading:2498776-Leukocyte Count,
pubmed-meshheading:2498776-Macrophages,
pubmed-meshheading:2498776-Male,
pubmed-meshheading:2498776-Middle Aged,
pubmed-meshheading:2498776-Monocytes,
pubmed-meshheading:2498776-T-Lymphocytes
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
The role of interstitial infiltrates in IgA nephropathy: a study with monoclonal antibodies.
|
| pubmed:affiliation |
Renal Unit, Guy's United Medical School, London, UK.
|
| pubmed:publicationType |
Journal Article
|