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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1989-7-11
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pubmed:abstractText |
The 3-keto derivatives of trehalose and sucrose respectively were prepared by a one-step enzymatic route using D-glucoside 3-dehydrogenase from Flavobacterium saccharophilum. Reductive amination of 3-ketotrehalose with ammonium acetate and sodium cyanoborohydride gave three compounds, 3-amino-3-deoxy-alpha-D-allopyranosyl alpha-D-glucopyranoside, 3-amino-3-deoxy-alpha-D-glucopyranosyl alpha-D-glucopyranoside (3-trehalosamine) and 3-amino-3-deoxy-alpha-D-mannopyranosyl alpha-D-glucopyranoside. From the reductive amination of 3-ketosucrose, 3-amino-3-deoxy-alpha-D-allopyranosyl beta-D-fructofuranoside and 3-amino-3-deoxy-alpha-D-glucopyranosyl beta-D-fructofuranoside were obtained. The antibiotic and glycohydrolase inhibitory activities of these 3-amino-3-deoxy derivatives were determined.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0021-8820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
585-90
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2498271-Amination,
pubmed-meshheading:2498271-Anti-Bacterial Agents,
pubmed-meshheading:2498271-Bacillus subtilis,
pubmed-meshheading:2498271-Cell Membrane,
pubmed-meshheading:2498271-Disaccharides,
pubmed-meshheading:2498271-Escherichia coli,
pubmed-meshheading:2498271-Flavobacterium,
pubmed-meshheading:2498271-Glucose Dehydrogenases,
pubmed-meshheading:2498271-Glycoside Hydrolases,
pubmed-meshheading:2498271-Hydrogenation,
pubmed-meshheading:2498271-Molecular Structure,
pubmed-meshheading:2498271-Mycobacterium,
pubmed-meshheading:2498271-Oxidation-Reduction,
pubmed-meshheading:2498271-Staphylococcus aureus,
pubmed-meshheading:2498271-Sucrose,
pubmed-meshheading:2498271-Trehalase,
pubmed-meshheading:2498271-Trehalose,
pubmed-meshheading:2498271-alpha-Glucosidases,
pubmed-meshheading:2498271-beta-Fructofuranosidase
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pubmed:year |
1989
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pubmed:articleTitle |
Preparation of 3-amino-3-deoxy derivatives of trehalose and sucrose and their activities.
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pubmed:affiliation |
School of Pharmacy, Hokuriku University, Kanazawa, Japan.
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pubmed:publicationType |
Journal Article
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