Linked Life Data

2498206

Source:http://linkedlifedata.com/resource/pubmed/id/2498206

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1989-6-23
pubmed:abstractText
Malnutrition may be a predisposing host factor in the development of exogenous-reinfection tuberculosis. Outbred Hartley guinea pigs were given isocaloric diets containing either 30% ovalbumin (control animals) or 10% ovalbumin (low-protein-fed [LP] animals). Equal numbers of control and LP animals were assigned to one of three infection groups: (i) primary pulmonary infection with a low-virulence, streptomycin-resistant (LVsr) isolate of Mycobacterium tuberculosis and then reinfection 6 weeks later by the same route with a high-virulence (HV) isolate; (ii) only the primary infection (LVsr isolate); and (iii) only the secondary infection (HV isolate). Each infection resulted in the development of 4 to 12 pulmonary tubercles. Guinea pigs were skin tested with purified protein derivative and killed 6 weeks after the second infection. Protein deprivation suppressed the dermal responses to purified protein derivative in all infection groups. Primary infection of well-nourished animals with the LVsr isolate induced significant protection against infection with the HV isolate in the reinfected group, based upon the numbers of viable mycobacteria in the lung and spleen. Protein malnutrition did not exacerbate disease in the reinfected group beyond that observed in malnourished animals infected with the HV isolate only, but neither did the infection with the LVsr isolate protect the LP animals against reinfection with the HV isolate. We conclude that malnutrition interferes with the protection normally afforded by primary infection but does not result in more severe disease in reinfected individuals than would be observed in singly infected subjects.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2498206-3097543, http://linkedlifedata.com/resource/pubmed/commentcorrection/2498206-3715981, http://linkedlifedata.com/resource/pubmed/commentcorrection/2498206-3717761, http://linkedlifedata.com/resource/pubmed/commentcorrection/2498206-3804439, http://linkedlifedata.com/resource/pubmed/commentcorrection/2498206-3932212, http://linkedlifedata.com/resource/pubmed/commentcorrection/2498206-4024270, http://linkedlifedata.com/resource/pubmed/commentcorrection/2498206-4964472, http://linkedlifedata.com/resource/pubmed/commentcorrection/2498206-6339390, http://linkedlifedata.com/resource/pubmed/commentcorrection/2498206-6396715, http://linkedlifedata.com/resource/pubmed/commentcorrection/2498206-6423543, http://linkedlifedata.com/resource/pubmed/commentcorrection/2498206-7040251, http://linkedlifedata.com/resource/pubmed/commentcorrection/2498206-910875
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1746-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1989
pubmed:articleTitle
Impact of protein malnutrition on exogenous reinfection with Mycobacterium tuberculosis.
pubmed:affiliation
Department of Medical Microbiology and Immunology, Texas A&M University, College Station 77843.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.