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pubmed:abstractText |
In mice, Ro 15-4513 reduced the anaesthesia induced by ethanol and some other general depressant drugs, but was less effective against others. The order of potency was, from greatest reduction to least, ethanol, t-butanol, trichloroethanol, urethane, chlormethiazode, pentobarbitone. Of the two gaseous anaesthetics that were tested, ether anaesthesia was reduced but halothane was not. These results appeared independent of the doses of depressant or of Ro 15-4513; the effect of Ro 15-4513 in reducing ethanol anaesthesia was blocked by flumazenil (Ro 15-1788). It would appear that the benzodiazepine receptor complex is of importance in the induction of anaesthesia, most significantly with ethanol and to a diminishing degree with the other general depressants tested.
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