Linked Life Data

2496455

Source:http://linkedlifedata.com/resource/pubmed/id/2496455

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1989-5-26
pubmed:abstractText
Helper T lymphocytes can only recognize mycobacterial antigens when they are presented by HLA class 2 molecules. Thus, these molecules may play an important role in the regulation of the immune response against mycobacteria. In this paper it is demonstrated that the T cells from individuals with different HLA class 2 molecules react to different mycobacterial antigens. These data indicate that HLA class 2 molecules are the products of immune response (Ir) genes for mycobacteria. Such genetically controlled differences in antimycobacterial T cell reactivity may explain the association of certain HLA class 2 alleles with a different course of mycobacterial infections and may have implications for vaccine development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0162-0886
pubmed:author
pubmed:issnType
Print
pubmed:volume
11 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S400-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Regulation of T cell responsiveness against mycobacterial antigens by HLA class 2 immune response genes.
pubmed:affiliation
Department of Immunohematology and Blood Bank, University Hospital, Leiden, The Netherlands.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't