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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1989-5-26
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pubmed:abstractText |
The molecular study of the erect wing (ewg) locus was initiated by isolating DNA in the 1A8-1B1 interval of the X chromosome. Previous developmental genetic analyses of the mutant alleles at the ewg locus have demonstrated that the wild-type ewg product is essential during embryogenesis and is required postembryonically at least for the development of the indirect flight muscle. To define the ewg-encoding DNA, chromosomal breakpoints that genetically flank the ewg locus were used. P-element-mediated transformation followed by subsequent rescue of the ewg-lethal alleles has defined a 11.5-kilobase genomic fragment as encoding the ewg locus. Northern blot analysis of transcription from this DNA has revealed a complex pattern of transcription with respect to both size and developmental profile. Tissue distribution of putative ewg transcription was examined by in situ hybridization to 6- to 14-h-old embryonic sections. These sections revealed that the expression of putative ewg messages is limited to the central nervous system-derived structures and not observed within the mesoderm during this developmental stage.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-100357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-16453459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-2578318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-289331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-2986850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-3004963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-3085954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-3107982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-3127258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-3917860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-3933004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-3986904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-410901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-6094014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-6116248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-6129675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-6289435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-6289436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-6312838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-6403869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-6488317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-6801424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-6806144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-6873458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-7060830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-7110311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2496301-97355
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
719-25
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:2496301-Animals,
pubmed-meshheading:2496301-Chromosome Mapping,
pubmed-meshheading:2496301-DNA,
pubmed-meshheading:2496301-Drosophila melanogaster,
pubmed-meshheading:2496301-Gene Expression Regulation,
pubmed-meshheading:2496301-Mutation,
pubmed-meshheading:2496301-Phenotype,
pubmed-meshheading:2496301-RNA Probes,
pubmed-meshheading:2496301-Tissue Distribution,
pubmed-meshheading:2496301-Transcription, Genetic,
pubmed-meshheading:2496301-Wing
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pubmed:year |
1989
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pubmed:articleTitle |
Molecular isolation and analysis of the erect wing locus in Drosophila melanogaster.
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pubmed:affiliation |
Department of Biology, Brandeis University, Waltham, Massachusetts 02254.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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