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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
2
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pubmed:dateCreated |
1989-5-22
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|
pubmed:abstractText |
A total of 70 patients were treated with intravesical instillations of Mitomycin-C (MMC) following transurethral resection for superficial bladder carcinoma. In this randomised prospective study the influence of 2 exposure times (0.5 and 1 h) was studied in relation to tumour recurrence, recurrence interval, tumour progression and toxicity. The number of patients with recurrent tumours was significantly lower in the 1-h group. Tumour progression was seen in only 2 patients in each group and all had primary or secondary carcinoma in situ of the bladder or prostatic urethra. Fourteen patients were excluded from further evaluation because of side effects. A longer instillation time over a longer period and a lower dose of MMC are recommended.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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|
pubmed:journal |
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|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0007-1331
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
176-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2495144-Administration, Intravesical,
pubmed-meshheading:2495144-Adult,
pubmed-meshheading:2495144-Aged,
pubmed-meshheading:2495144-Aged, 80 and over,
pubmed-meshheading:2495144-Carcinoma, Transitional Cell,
pubmed-meshheading:2495144-Carcinoma in Situ,
pubmed-meshheading:2495144-Clinical Trials as Topic,
pubmed-meshheading:2495144-Drug Administration Schedule,
pubmed-meshheading:2495144-Female,
pubmed-meshheading:2495144-Follow-Up Studies,
pubmed-meshheading:2495144-Humans,
pubmed-meshheading:2495144-Male,
pubmed-meshheading:2495144-Middle Aged,
pubmed-meshheading:2495144-Mitomycin,
pubmed-meshheading:2495144-Mitomycins,
pubmed-meshheading:2495144-Neoplasm Recurrence, Local,
pubmed-meshheading:2495144-Neoplasm Staging,
pubmed-meshheading:2495144-Prospective Studies,
pubmed-meshheading:2495144-Random Allocation,
pubmed-meshheading:2495144-Urinary Bladder Neoplasms
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pubmed:year |
1989
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pubmed:articleTitle |
Recurrence of superficial bladder carcinoma after intravesical instillation of mitomycin-C. Comparison of exposure times.
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pubmed:affiliation |
Department of Urology, Leiden University Hospital, The Netherlands.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
|
