Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1989-5-15
|
| pubmed:abstractText |
The relationships of plasma lipid and apolipoprotein (apo) concentrations to hepatic low-density lipoprotein (LDL) receptor activity were examined in 21 subjects (16 females, 5 males), who were undergoing laparotomy for non-neoplastic disease (cholecystectomy in 16). None had familial hypercholesterolemia, or renal, endocrine or hepatic disease. Ages were 37-77 years (mean, 58 years), plasma cholesterol concentrations 4.09-6.72 mmol/l (5.38) and plasma triacylglycerol concentrations 0.75-2.35 mmol/l (1.36). Receptor activity was quantified in vitro as the total saturable binding and EDTA-suppressible binding (representing apoB,E receptors) of 125I-labelled human LDL (15 micrograms protein/ml) by liver homogenate at 37 degrees C. There were no significant differences between men and women in 125I-labeled LDL binding. In the pooled data, EDTA-suppressible binding averaged 50 ng 125I-LDL protein/mg cell protein (S.D., 15). Total saturable binding averaged 2-fold greater (mean, 101 ng/mg; S.D., 32). Plasma cholesterol, LDL cholesterol and apoB concentrations were negative functions of both EDTA-suppressible binding and total saturable binding, but the correlations with EDTA-suppressible binding were stronger (cholesterol: r = -0.59, P less than 0.01; LDL cholesterol: r = -0.48, P less than 0.05; apoB: r = -0.61, P less than 0.01). Plasma triacylglycerol, high-density lipoprotein cholesterol and apoA-I concentrations were not related to either measure of receptor activity. These results provide evidence that the activity of apoB,E receptors in the liver is a major determinant of the plasma LDL concentration in middle-aged and elderly humans.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein A-I,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins A,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins B,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Edetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Iodine Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0006-3002
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
3
|
| pubmed:volume |
1002
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
245-55
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2495023-Adult,
pubmed-meshheading:2495023-Aged,
pubmed-meshheading:2495023-Animals,
pubmed-meshheading:2495023-Apolipoprotein A-I,
pubmed-meshheading:2495023-Apolipoproteins,
pubmed-meshheading:2495023-Apolipoproteins A,
pubmed-meshheading:2495023-Apolipoproteins B,
pubmed-meshheading:2495023-Cattle,
pubmed-meshheading:2495023-Cholesterol,
pubmed-meshheading:2495023-Cholesterol, HDL,
pubmed-meshheading:2495023-Cholesterol, LDL,
pubmed-meshheading:2495023-Edetic Acid,
pubmed-meshheading:2495023-Female,
pubmed-meshheading:2495023-Humans,
pubmed-meshheading:2495023-Iodine Radioisotopes,
pubmed-meshheading:2495023-Kinetics,
pubmed-meshheading:2495023-Lipids,
pubmed-meshheading:2495023-Lipoproteins, LDL,
pubmed-meshheading:2495023-Liver,
pubmed-meshheading:2495023-Male,
pubmed-meshheading:2495023-Middle Aged,
pubmed-meshheading:2495023-Rabbits,
pubmed-meshheading:2495023-Rats,
pubmed-meshheading:2495023-Receptors, LDL,
pubmed-meshheading:2495023-Triglycerides
|
| pubmed:year |
1989
|
| pubmed:articleTitle |
Human hepatic low-density lipoprotein receptors: associations of receptor activities in vitro with plasma lipid and apolipoprotein concentrations in vivo.
|
| pubmed:affiliation |
Department of Chemical Pathology and Metabolic Disorders, St. Thomas' Campus, United Medical School of Guy's Hospital, London U.K.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|